2019
Lower synaptic density is associated with depression severity and network alterations
Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications 2019, 10: 1529. PMID: 30948709, PMCID: PMC6449365, DOI: 10.1038/s41467-019-09562-7.Peer-Reviewed Original ResearchConceptsMajor depressive disorderPost-traumatic stress disorderLower synaptic densitySynaptic densityPositron emission tomographyFunctional connectivityNetwork alterationsSynaptic vesicle glycoprotein 2ASymptoms of depressionSynaptic lossDepressive disorderHealthy controlsNerve terminalsDepressive symptomsDepression severityUnmedicated individualsSynaptic connectionsEmission tomographyStress disorderVivo evidenceSymptomsDepressionSeverityDisordersAlterations
2017
Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey‐Smith S, Fowler C, Ellis K, Martins RN, Salvado O, Doré V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Pietrzak RH, Maruff P, Imaging B. Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study. International Journal Of Geriatric Psychiatry 2017, 33: 405-413. PMID: 28736899, PMCID: PMC5773367, DOI: 10.1002/gps.4761.Peer-Reviewed Original ResearchMeSH KeywordsAgedAllelesAlzheimer DiseaseAnxiety DisordersApolipoprotein E4AttentionBrain-Derived Neurotrophic FactorCognitionDepressive DisorderDisease ProgressionExecutive FunctionFemaleHumansLogistic ModelsMaleMiddle AgedPositron-Emission TomographyProspective StudiesQuality of LifeRisk FactorsSex FactorsConceptsOlder adultsAnxiety symptomsPredominant trajectoriesRisk factorsLatent growth mixture modelingAlzheimer's diseaseApolipoprotein epsilon 4 alleleSex-specific risk factorsLower attentional functionBinary logistic regression analysisEpsilon 4 alleleElevated depressive symptomsGrowth mixture modelingLogistic regression analysisQuality of lifePositron emission tomographyNormal older adultsSubthreshold depressiveMale sexBaseline predictorsDepressive symptomsVal66Met alleleClinical depressionLower executive functionAnxiety trajectories
2016
β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
Holmes SE, Esterlis I, Mazure CM, Lim YY, Ames D, Rainey-Smith S, Martins RN, Salvado O, Dore V, Villemagne VL, Rowe CC, Laws SM, Masters CL, Maruff P, Pietrzak RH, Australian Imaging B. β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men. American Journal Of Geriatric Psychiatry 2016, 24: 1191-1195. PMID: 27742526, DOI: 10.1016/j.jagp.2016.08.007.Peer-Reviewed Original ResearchConceptsBDNF genotypeNormal older womenAnxiety symptomsOlder adultsΕ4 carriageOlder womenDepressive symptomsΒ-amyloidGreater severityAustralian Imaging BiomarkersNon-ε4 carriersSeverity of depressiveMet allele carriersSeverity of anxietyGreater depressive symptomsNormal older adultsGreater anxiety symptomsLifestyle StudyΕ4 carriersAPOE genotypeAllele carriersAnalysis of covarianceImaging biomarkersSymptomsDepressive