2012
Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients
Waldron-Lynch F, Henegariu O, Deng S, Preston-Hurlburt P, Tooley J, Flavell R, Herold KC. Teplizumab Induces Human Gut-Tropic Regulatory Cells in Humanized Mice and Patients. Science Translational Medicine 2012, 4: 118ra12. PMID: 22277969, PMCID: PMC4131554, DOI: 10.1126/scitranslmed.3003401.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, Monoclonal, HumanizedCD3 ComplexCell MovementDiabetes Mellitus, Type 1Forkhead Transcription FactorsGastrointestinal TractHumansHypoglycemic AgentsInterleukin-10Intestine, SmallL-SelectinMiceMucous MembraneNatalizumabOligonucleotide Array Sequence AnalysisReceptors, CCR6T-Lymphocytes, RegulatoryConceptsHumanized micePeripheral circulationSmall intestineType 1 diabetes mellitusNovel immunologic mechanismIL-10 expressionTreatment of patientsType 1 diabetesSecondary lymph organsHuman immune cellsT cell migrationMechanism of actionGut-tropicImmunologic mechanismsRegulatory cellsDiabetes mellitusImmune therapyInterleukin-10Immune cellsRegulatory cytokinesClinical trialsPreclinical modelsClinical studiesT cellsHuman hematopoietic stem cells
2005
Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue
Dai Z, Nasr IW, Reel M, Deng S, Diggs L, Larsen CP, Rothstein DM, Lakkis FG. Impaired Recall of CD8 Memory T Cells in Immunologically Privileged Tissue. The Journal Of Immunology 2005, 174: 1165-1170. PMID: 15661869, DOI: 10.4049/jimmunol.174.3.1165.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCD8-Positive T-LymphocytesCell MovementEpitopes, T-LymphocyteFas ReceptorGraft RejectionImmunologic MemoryIslets of Langerhans TransplantationKi-1 AntigenKidneyMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutMice, Mutant StrainsMice, TransgenicTestisTransplantation, HeterotopicConceptsMemory T cellsCD8 memory T cellsT cellsForeign AgsPrivileged tissuesT cell-mediated rejectionCell-mediated rejectionPancreatic islet allograftsDelayed graft rejectionTNFR family membersPrivileged siteIntratesticular graftsGraft rejectionIslet allograftsImmunosuppressive mechanismsImmune privilegeAllogeneic graftsDiabetic miceKidney capsuleSame AgTumor cellsGraftImpaired recallFamily membersCells
2001
Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models
Rothstein D, Livak M, Kishimoto K, Ariyan C, Qian H, Fecteau S, Sho M, Deng S, Zheng X, Sayegh M, Basadonna G. Targeting Signal 1 Through CD45RB Synergizes with CD40 Ligand Blockade and Promotes Long Term Engraftment and Tolerance in Stringent Transplant Models. The Journal Of Immunology 2001, 166: 322-329. PMID: 11123308, DOI: 10.4049/jimmunol.166.1.322.Peer-Reviewed Original ResearchMeSH KeywordsAdjuvants, ImmunologicAnimalsAntibodies, BlockingAntibodies, MonoclonalB-LymphocytesCD40 LigandCD8-Positive T-LymphocytesCell MovementCytokinesDrug Therapy, CombinationGraft SurvivalIslets of Langerhans TransplantationLeukocyte Common AntigensMaleMiceMice, Inbred BALB CMice, Inbred C57BLModels, ImmunologicalMonocytesProtein IsoformsSignal TransductionSkin TransplantationTransplantation ToleranceConceptsCostimulatory blockadeCD40 ligand blockadeStringent transplant modelSkin allograft survivalBlockade of CD28Induction of toleranceTh2 cytokine expressionLong-term engraftmentImmunogenic allograftAllograft survivalAllograft toleranceAllograft rejectionC57BL/6 recipientsCD8 cellsIslet allograftsTh1 cytokinesTransplant modelCostimulatory pathwayCytokine expressionCD40 ligandMurine modelB cellsTerm engraftmentBlockadeEngraftment