Anti‐Siglec‐15 Antibody Prevents Marked Bone Loss after Acute Spinal Cord Injury‐Induced Immobilization in Rats
Peng Y, Langermann S, Kothari P, Liu L, Zhao W, Hu Y, Chen Z, de Lima Perini M, Li J, Cao J, Guo X, Chen L, Bauman W, Qin W. Anti‐Siglec‐15 Antibody Prevents Marked Bone Loss after Acute Spinal Cord Injury‐Induced Immobilization in Rats. JBMR Plus 2023, 7: e10825. PMID: 38130761, PMCID: PMC10731123, DOI: 10.1002/jbm4.10825.Peer-Reviewed Original ResearchAcute spinal cord injurySpinal cord injuryTrabecular bone volumeBone lossBone resorptionBone volumeBone formationRat model of acute spinal cord injuryCultures of bone marrow cellsAntiresorptive agent denosumabInhibition of bone formationSiglec-15Sublesional bone lossBone mineral densityModel of acute spinal cord injuryPrevent bone lossBone marrow cellsInhibit bone lossInhibiting osteoclast maturationMale Wistar ratsEx vivo cultureInhibit bone resorptionSpinal cord transectionAcute SCI modelAntiresorptive agents