2021
Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development
Xia S, VanKuren NW, Chen C, Zhang L, Kemkemer C, Shao Y, Jia H, Lee U, Advani AS, Gschwend A, Vibranovski MD, Chen S, Zhang YE, Long M. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. PLOS Genetics 2021, 17: e1009654. PMID: 34242211, PMCID: PMC8270118, DOI: 10.1371/journal.pgen.1009654.Peer-Reviewed Original ResearchConceptsNew genesPhenotypic effectsEssential functionsLong evolutionary time scalesDevelopment of DrosophilaEvolutionary time scalesDrosophila developmentDrosophila genusEssential genesGene essentialityRNAi libraryYoung genesGenomic analysisCRISPR knockoutKnockout approachGenetic basisKnockdown experimentsComputational identificationGene effectsGenesDuplicate copiesRapid evolutionDrosophilaKnockdown efficiencyDistant ancestors
2012
Reshaping of global gene expression networks and sex‐biased gene expression by integration of a young gene
Chen S, Ni X, Krinsky BH, Zhang YE, Vibranovski MD, White KP, Long M. Reshaping of global gene expression networks and sex‐biased gene expression by integration of a young gene. The EMBO Journal 2012, 31: 2798-2809. PMID: 22543869, PMCID: PMC3380208, DOI: 10.1038/emboj.2012.108.Peer-Reviewed Original ResearchConceptsSex-biased gene expressionNew genesGene expressionPre-existing genesCo-evolved interactionsGenomic binding profileNew gene networksComparative expression profilingOrgan expression patternsGene expression networksEssential biological processesDiverse taxaYoung genesExpression networksGene networksRelated speciesGenetic networksDownstream genesGenomic levelExpression profilingExpression patternsBiological processesGenesMale fecundityCAF40Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila
Chen S, Spletter M, Ni X, White KP, Luo L, Long M. Frequent Recent Origination of Brain Genes Shaped the Evolution of Foraging Behavior in Drosophila. Cell Reports 2012, 1: 118-132. PMID: 22832161, PMCID: PMC4382513, DOI: 10.1016/j.celrep.2011.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PhysiologicalAgingAmino Acid SequenceAnimalsArthropod AntennaeBrainDrosophila melanogasterDrosophila ProteinsEvolution, MolecularFeeding BehaviorFemaleGene Expression ProfilingGene Expression Regulation, DevelopmentalGenes, InsectMaleMolecular Sequence DataMushroom BodiesNeuronsSelection, GeneticSex CharacteristicsSynaptic TransmissionTranscriptomeConceptsNew genesForaging behaviorMushroom bodiesYoung retrogenesAdaptive evolutionPhenotypic evolutionEvolutionary signaturesYoung genesNatural selectionGenetic basisBrain genesExpression profilingComparative behavioral analysisBrain evolutionGenesOlfactory circuitDrosophilaNew functionsAnimal behaviorNeuronal expressionExpressionRetrogenesNeural circuitsEvolutionRecent evolution
2011
Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages
Chen S, Yang H, Krinsky BH, Zhang A, Long M. Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. Fly 2011, 5: 345-351. PMID: 21946255, PMCID: PMC3266076, DOI: 10.4161/fly.5.4.17808.Peer-Reviewed Original ResearchConceptsYoung genesConstitutive knockdownAdult stageD. melanogaster subgroupEvolution of developmentImportant functional roleMelanogaster subgroupDrosophila melanogasterLethal phenotypeNew genesCommon ancestorImportant traitsNatural selectionEndopeptidase genePhenotypic effectsLife historyWildtype levelsMultiple phenotypesGenesFunctional roleGenetic componentRapid evolutionMale fertilityFemale fertilityKnockdown