2024
Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessmentIntraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage
Willms J, Boss J, Huo S, Wolf S, Westphal L, Bögli S, Inauen C, Baumann D, Fröhlich J, Keller E. Intraparenchymal near-infrared spectroscopy for detection of delayed cerebral ischemia in poor-grade aneurysmal subarachnoid hemorrhage. Journal Of Neuroscience Methods 2024, 406: 110113. PMID: 38537749, DOI: 10.1016/j.jneumeth.2024.110113.Peer-Reviewed Original ResearchDetection of delayed cerebral ischemiaAneurysmal subarachnoid hemorrhagePoor-grade aneurysmal subarachnoid hemorrhagePerfusion deficitsSubarachnoid hemorrhageIntracranial pressureCerebral ischemiaMedian valuePerfusion CT scansCerebral perfusion deficitsDetect perfusion deficitsBrain tissue oxygen pressureMeasurement of intracranial pressureCT scanTissue oxygen pressureComatose patientsCerebral infarctionPatientsNear-infrared spectroscopyMultimodal neuromonitoringPatient collectivesHbtotalPerfusionInfarctionPbtO2A supervised, externally validated machine learning model for artifact and drainage detection in high-resolution intracranial pressure monitoring data.
Huo S, Nelde A, Meisel C, Scheibe F, Meisel A, Endres M, Vajkoczy P, Wolf S, Willms J, Boss J, Keller E. A supervised, externally validated machine learning model for artifact and drainage detection in high-resolution intracranial pressure monitoring data. Journal Of Neurosurgery 2024, 141: 509-517. PMID: 38489814, DOI: 10.3171/2023.12.jns231670.Peer-Reviewed Original ResearchMachine learningReal-time artifact removalML-based solutionsSequential feature selectionML-based algorithmsHistogram-based gradientMachine learning modelsCross-validationFeature selectionHyperparameter optimizationArtifact removalML applicationsMultiple biosensorsRandom treeLearning modelsSupervised modelsGrid searchNormal signalMulticlass areaMonitoring signalsValidation cycleDatasetNested 5-fold cross-validationMonitoring dataMachine
2023
Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke
Sperber P, Gebert P, Broersen L, Kufner A, Huo S, Piper S, Teegen B, Heuschmann P, Prüss H, Endres M, Liman T, Siegerink B. Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke. Brain Behavior & Immunity - Health 2023, 34: 100705. PMID: 38033615, PMCID: PMC10684375, DOI: 10.1016/j.bbih.2023.100705.Peer-Reviewed Original ResearchNMDAR1-ABDepressive symptomsHigh titersIschemic strokeProspective cohortEpidemiological Studies Depression ScaleSevere neuropsychiatric symptomsSevere depressive symptomsAutoimmune encephalitisSeronegative patientsAntibody seropositivityIncident strokeSeropositive patientsNeuropsychiatric symptomsSymptoms yearsPatientsLow titersSymptomsTitersCell-based assaysSeropositivityCohortStrokeCESEncephalitisVideo Object Detection for Privacy-Preserving Patient Monitoring in Intensive Care
Emberger R, Boss J, Baumann D, Seric M, Huo S, Tuggener L, Keller E, Stadelmann T. Video Object Detection for Privacy-Preserving Patient Monitoring in Intensive Care. 2023, 00: 85-88. DOI: 10.1109/sds57534.2023.00019.Peer-Reviewed Original ResearchVideo object detectionClinical decision support systemObject detection methodShelf object detectorDecision support systemPatient monitoringImage color channelsPrivacy restrictionsVideo framesIT infrastructureObject detectionObject detectorObject classesHardware constraintsTemporal consistencySupport systemColor channelsBaseline modelImproved detection rateDetection methodReliable classificationProprietary datasetUnwanted artifactsInfrastructureInformation contentMachine learning-based prediction of clinical outcomes after first-ever ischemic stroke
Fast L, Temuulen U, Villringer K, Kufner A, Ali H, Siebert E, Huo S, Piper S, Sperber P, Liman T, Endres M, Ritter K. Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke. Frontiers In Neurology 2023, 14: 1114360. PMID: 36895902, PMCID: PMC9990416, DOI: 10.3389/fneur.2023.1114360.Peer-Reviewed Original ResearchMini-Mental State ExaminationClinical outcomesBarthel IndexIschemic strokePrognostic factorsPatient dischargeCognitive functionFunctional recovery outcomesFurther patient careHealth Stroke ScaleEpidemiologic Studies Depression ScaleIschemic stroke patientsStroke ScaleAcute strokeProspective cohortRankin ScaleFunctional recoveryPrognostic featuresStroke patientsModified Telephone InterviewTreatment strategiesDepression ScaleIndividual patientsState ExaminationHealthcare providersAssociations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Arends C, Liman T, Strzelecka P, Kufner A, Löwe P, Huo S, Stein C, Piper S, Tilgner M, Sperber P, Dimitriou S, Heuschmann P, Hablesreiter R, Harms C, Bullinger L, Weber J, Endres M, Damm F. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke. Blood 2023, 141: 787-799. PMID: 36441964, DOI: 10.1182/blood.2022017661.Peer-Reviewed Original ResearchConceptsComposite end pointPrimary composite end pointRecurrent vascular eventsVascular eventsIschemic strokeClonal hematopoiesisInterleukin-6Risk factorsHigh-sensitivity C-reactive proteinLarge artery atherosclerosis strokeVascular cell adhesion molecule-1Cell adhesion molecule-1Secondary vascular eventsIncident ischemic strokeMultivariable Cox regressionIndependent risk factorC-reactive proteinRisk of atherosclerosisShorter overall survivalMajor risk factorWhite matter lesionsAdhesion molecule-1Peripheral blood DNAPrecision medicine approachIL-6 receptor
2022
Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B)
Stillfried M, Sperber P, Broersen L, Huo S, Piper S, Heuschmann P, Endres M, Siegerink B, Liman T. Low ankle-brachial index and cognitive function after stroke—the PROSpective with Incident Stroke Berlin (PROSCIS-B). Frontiers In Neurology 2022, 13: 963262. PMID: 36247749, PMCID: PMC9554657, DOI: 10.3389/fneur.2022.963262.Peer-Reviewed Original ResearchLow ankle-brachial indexAnkle-brachial indexCognitive functionIschemic strokeRelative riskCognitive impairmentMontreal Cognitive AssessmentGeneralized atherosclerosisProspective cohortRisk factorsGeneral populationState ExaminationCognitive declinePatientsCognitive statusTelephone interviewsMini-MentalCognitive AssessmentStrokeBaselineImpairmentRiskMixed modelsTICSAtherosclerosisSerum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B)
Sperber P, Gebert P, Broersen L, Huo S, Piper S, Teegen B, Heuschmann P, Prüss H, Endres M, Liman T, Siegerink B. Serum anti-NMDA-receptor antibodies and cognitive function after ischemic stroke (PROSCIS-B). Journal Of Neurology 2022, 269: 5521-5530. PMID: 35718820, PMCID: PMC9468072, DOI: 10.1007/s00415-022-11203-x.Peer-Reviewed Original ResearchConceptsSeronegative patientsIschemic strokeCognitive functionNMDAR1-ABLow titersHigh titersFavorable cognitive outcomeModerate ischemic strokeAntibody seropositivityProspective cohortReceptor antibodiesSerum titersPatientsSeropositivityCognitive statusStrokeTelephone interviewsInverse probabilityTitersCognitive outcomesCell-based assaysTICSLong termSerostatusResultsDataIntravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy
Huo S, Ferse C, Bösl F, Reincke S, Enghard P, Hinrichs C, Treskatsch S, Angermair S, Eckardt K, Audebert H, Ploner C, Endres M, Prüss H, Franke C, Scheibe F. Intravenous immunoglobulins for treatment of severe COVID-19-related acute encephalopathy. Journal Of Neurology 2022, 269: 4013-4020. PMID: 35538168, PMCID: PMC9089297, DOI: 10.1007/s00415-022-11152-5.Peer-Reviewed Original ResearchSARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
Reincke S, Yuan M, Kornau H, Corman V, van Hoof S, Sánchez-Sendin E, Ramberger M, Yu W, Hua Y, Tien H, Schmidt M, Schwarz T, Jeworowski L, Brandl S, Rasmussen H, Homeyer M, Stöffler L, Barner M, Kunkel D, Huo S, Horler J, von Wardenburg N, Kroidl I, Eser T, Wieser A, Geldmacher C, Hoelscher M, Gänzer H, Weiss G, Schmitz D, Drosten C, Prüss H, Wilson I, Kreye J. SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies. Science 2022, 375: eabm5835. PMID: 35076281, PMCID: PMC8939768, DOI: 10.1126/science.abm5835.Peer-Reviewed Original ResearchConceptsCross-reactive antibodiesReceptor-binding domain antibodiesMajor antibody classCOVID-19 patientsSARS-CoV-2Next-generation vaccinesInfection elicitsVaccinated individualsAntibody responseAntibody classAntigenic driftWild-type virusPatientsBeta variantAntibodiesClonotypesDomain antibodiesVaccineMutationsSerum
2021
The Dynamic of Extracellular Vesicles in Patients With Subacute Stroke: Results of the “Biomarkers and Perfusion—Training-Induced Changes After Stroke” (BAPTISe) Study
Jödicke R, Huo S, Kränkel N, Piper S, Ebinger M, Landmesser U, Flöel A, Endres M, Nave A. The Dynamic of Extracellular Vesicles in Patients With Subacute Stroke: Results of the “Biomarkers and Perfusion—Training-Induced Changes After Stroke” (BAPTISe) Study. Frontiers In Neurology 2021, 12: 731013. PMID: 34819906, PMCID: PMC8606784, DOI: 10.3389/fneur.2021.731013.Peer-Reviewed Original ResearchBarthel IndexFunctional outcomeCardiovascular eventsSubacute strokeExtracellular vesiclesSubacute ischemic stroke patientsLong-term cardiovascular outcomesWorse Barthel IndexIschemic stroke patientsLower Barthel IndexRecurrent cardiovascular eventsWorse functional outcomeSerial blood samplesLevels of EVsRegression analysisMixed-model regression analysisMixed model regression analysisCardiovascular outcomesIschemic strokeFluorescence-activated cellStroke patientsTrial interventionAerobic trainingClinical trialsLower increaseHigh‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke
Scheitz J, Lim J, Broersen L, Ganeshan R, Huo S, Sperber P, Piper S, Heuschmann P, Audebert H, Nolte C, Siegerink B, Endres M, Liman T. High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke. Journal Of The American Heart Association 2021, 10: e018326. PMID: 33982599, PMCID: PMC8200699, DOI: 10.1161/jaha.120.018326.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsModerate ischemic strokeVascular eventsCardiac troponin TIschemic strokePrimary outcomeHs-cTnTCox proportional hazards regression analysisTroponin THigh-sensitivity cardiac troponin TProportional hazards regression analysisSensitivity cardiac troponin TFirst ischemic strokeCardiac troponin levelsHazards regression analysisHs-cTnT levelsIndividualized risk stratificationBackground Recent evidenceUpper reference limitDose-response relationshipCause deathRecurrent strokeTroponin levelsStudy entryVascular risk
2020
Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke: PROSCIS-B.
Huo S, Kränkel N, Nave A, Sperber P, Rohmann J, Piper S, Heuschmann P, Landmesser U, Endres M, Siegerink B, Liman T. Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke: PROSCIS-B. Neurology 2020, 96: e937-e946. PMID: 33184230, DOI: 10.1212/wnl.0000000000011223.Peer-Reviewed Original ResearchConceptsPlatelet-derived MVsCardiovascular outcomesCause mortalityMyocardial infarctionLong-term cardiovascular outcomesCox proportional hazards modelLeukocyte-derived microvesiclesClass II evidenceWorse cardiovascular outcomesLong-term prognosisKaplan-Meier curvesPlatelet-derived microvesiclesProportional hazards modelRecurrent strokeCardiovascular riskEndothelial dysfunctionIschemic strokeProspective cohortHighest quartileStroke patientsVascular inflammationMild strokeEndothelial microvesiclesLowest quartileHazards modelCoagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke
Rohmann J, Huo S, Sperber P, Piper S, Rosendaal F, Heuschmann P, Endres M, Liman T, Siegerink B. Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke. Journal Of Thrombosis And Haemostasis 2020, 18: 3316-3324. PMID: 32935900, DOI: 10.1111/jth.15092.Peer-Reviewed Original ResearchConceptsFirst ischemic strokeIschemic strokeCoagulation factor XIIVascular outcomesHazard ratioRisk factorsActivity levelsFactor XIICox proportional hazards modelIschemic stroke eventsRecurrent vascular eventsWorse vascular outcomesCardiovascular risk factorsIschemic stroke patientsFirst thrombotic eventSecondary eventsProportional hazards modelModerate ischemic stroke patientsFactor activity levelsRecurrent strokeCause mortalityProspective cohortVascular eventsThrombotic eventsStroke events
2019
Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
Major S, Huo S, Lemale C, Siebert E, Milakara D, Woitzik J, Gertz K, Dreier J. Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury. GeroScience 2019, 42: 57-80. PMID: 31820363, PMCID: PMC7031471, DOI: 10.1007/s11357-019-00142-7.Peer-Reviewed Original ResearchConceptsDepression of activityDirect electrophysiological evidenceMigraine auraNeurological deficitsPathophysiological correlatesGray matterMassive glutamate releaseMassive ion translocationTransient ischemic attackFocal neurological deficitsCerebral amyloid angiopathyAneurysmal subarachnoid hemorrhageElectrophysiological evidenceMass injuryBrain gray matterIschemic attackMigraine strokeDendritic beadingAmyloid angiopathyGlutamate releaseSubarachnoid hemorrhageDirect current potentialNeuronal somataClinical distinctionIschemic tissueSerum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B)
Sperber P, Siegerink B, Huo S, Rohmann J, Piper S, Prüss H, Heuschmann P, Endres M, Liman T. Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B). Stroke 2019, 50: 3213-3219. PMID: 31526121, DOI: 10.1161/strokeaha.119.026100.Peer-Reviewed Original ResearchConceptsSecondary vascular eventsFunctional outcomeVascular eventsHigh titersNMDAR1-ABSeronegative patientsSeropositive patientsFirst strokeLong-term clinical outcomesLong-term functional outcomeCombined end pointRecurrent vascular eventsOutcomes of patientsPoor functional outcomeSub-group analysisOutcomes of interestAnti-NMDAAutoimmune encephalitisCardiovascular riskProspective cohortRankin ScaleHazard ratioClinical outcomesNeuroprotective effectsReceptor antibodies