2024
Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessment
2023
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Arends C, Liman T, Strzelecka P, Kufner A, Löwe P, Huo S, Stein C, Piper S, Tilgner M, Sperber P, Dimitriou S, Heuschmann P, Hablesreiter R, Harms C, Bullinger L, Weber J, Endres M, Damm F. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke. Blood 2023, 141: 787-799. PMID: 36441964, DOI: 10.1182/blood.2022017661.Peer-Reviewed Original ResearchConceptsComposite end pointPrimary composite end pointRecurrent vascular eventsVascular eventsIschemic strokeClonal hematopoiesisInterleukin-6Risk factorsHigh-sensitivity C-reactive proteinLarge artery atherosclerosis strokeVascular cell adhesion molecule-1Cell adhesion molecule-1Secondary vascular eventsIncident ischemic strokeMultivariable Cox regressionIndependent risk factorC-reactive proteinRisk of atherosclerosisShorter overall survivalMajor risk factorWhite matter lesionsAdhesion molecule-1Peripheral blood DNAPrecision medicine approachIL-6 receptor
2022
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
Reincke S, Yuan M, Kornau H, Corman V, van Hoof S, Sánchez-Sendin E, Ramberger M, Yu W, Hua Y, Tien H, Schmidt M, Schwarz T, Jeworowski L, Brandl S, Rasmussen H, Homeyer M, Stöffler L, Barner M, Kunkel D, Huo S, Horler J, von Wardenburg N, Kroidl I, Eser T, Wieser A, Geldmacher C, Hoelscher M, Gänzer H, Weiss G, Schmitz D, Drosten C, Prüss H, Wilson I, Kreye J. SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies. Science 2022, 375: eabm5835. PMID: 35076281, PMCID: PMC8939768, DOI: 10.1126/science.abm5835.Peer-Reviewed Original ResearchConceptsCross-reactive antibodiesReceptor-binding domain antibodiesMajor antibody classCOVID-19 patientsSARS-CoV-2Next-generation vaccinesInfection elicitsVaccinated individualsAntibody responseAntibody classAntigenic driftWild-type virusPatientsBeta variantAntibodiesClonotypesDomain antibodiesVaccineMutationsSerum
2021
High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke
Scheitz J, Lim J, Broersen L, Ganeshan R, Huo S, Sperber P, Piper S, Heuschmann P, Audebert H, Nolte C, Siegerink B, Endres M, Liman T. High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke. Journal Of The American Heart Association 2021, 10: e018326. PMID: 33982599, PMCID: PMC8200699, DOI: 10.1161/jaha.120.018326.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsModerate ischemic strokeVascular eventsCardiac troponin TIschemic strokePrimary outcomeHs-cTnTCox proportional hazards regression analysisTroponin THigh-sensitivity cardiac troponin TProportional hazards regression analysisSensitivity cardiac troponin TFirst ischemic strokeCardiac troponin levelsHazards regression analysisHs-cTnT levelsIndividualized risk stratificationBackground Recent evidenceUpper reference limitDose-response relationshipCause deathRecurrent strokeTroponin levelsStudy entryVascular risk
2020
Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke: PROSCIS-B.
Huo S, Kränkel N, Nave A, Sperber P, Rohmann J, Piper S, Heuschmann P, Landmesser U, Endres M, Siegerink B, Liman T. Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke: PROSCIS-B. Neurology 2020, 96: e937-e946. PMID: 33184230, DOI: 10.1212/wnl.0000000000011223.Peer-Reviewed Original ResearchConceptsPlatelet-derived MVsCardiovascular outcomesCause mortalityMyocardial infarctionLong-term cardiovascular outcomesCox proportional hazards modelLeukocyte-derived microvesiclesClass II evidenceWorse cardiovascular outcomesLong-term prognosisKaplan-Meier curvesPlatelet-derived microvesiclesProportional hazards modelRecurrent strokeCardiovascular riskEndothelial dysfunctionIschemic strokeProspective cohortHighest quartileStroke patientsVascular inflammationMild strokeEndothelial microvesiclesLowest quartileHazards model
2019
Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B)
Sperber P, Siegerink B, Huo S, Rohmann J, Piper S, Prüss H, Heuschmann P, Endres M, Liman T. Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B). Stroke 2019, 50: 3213-3219. PMID: 31526121, DOI: 10.1161/strokeaha.119.026100.Peer-Reviewed Original ResearchConceptsSecondary vascular eventsFunctional outcomeVascular eventsHigh titersNMDAR1-ABSeronegative patientsSeropositive patientsFirst strokeLong-term clinical outcomesLong-term functional outcomeCombined end pointRecurrent vascular eventsOutcomes of patientsPoor functional outcomeSub-group analysisOutcomes of interestAnti-NMDAAutoimmune encephalitisCardiovascular riskProspective cohortRankin ScaleHazard ratioClinical outcomesNeuroprotective effectsReceptor antibodies