2024
Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons
Rivier C, Singh S, Senff J, Tack R, Marini S, Clocchiatti-Tuozzo S, Huo S, Renedo D, Papier K, Conroy M, Littlejohns T, Chemali Z, Kourkoulis C, Payabvash S, Newhouse A, Westover M, Lazar R, Pikula A, Ibrahim S, Howard V, Howard G, Brouwers H, Van Duijn C, Fricchione G, Tanzi R, Yechoor N, Sheth K, Anderson C, Rosand J, Falcone G. Brain Care Score and Neuroimaging Markers of Brain Health in Asymptomatic Middle-Age Persons. Neurology 2024, 103: e209687. PMID: 39052961, DOI: 10.1212/wnl.0000000000209687.Peer-Reviewed Original ResearchConceptsCare scoresUK BiobankWhite matter hyperintensitiesHealth-related behaviorsMarkers of brain healthMiddle-aged personsStroke risk factorsProspective cohort studyMultivariate linear regressionEmpower patientsSilent cerebrovascular diseaseBrain careWhite matter hyperintensities progressionDementia historyHealth declineInvestigate associationsCohort studyBrain healthNeuroimaging markersHigher scoresRisk factorsMean diffusivityCerebrovascular diseaseFractional anisotropyImaging assessment
2022
SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies
Reincke S, Yuan M, Kornau H, Corman V, van Hoof S, Sánchez-Sendin E, Ramberger M, Yu W, Hua Y, Tien H, Schmidt M, Schwarz T, Jeworowski L, Brandl S, Rasmussen H, Homeyer M, Stöffler L, Barner M, Kunkel D, Huo S, Horler J, von Wardenburg N, Kroidl I, Eser T, Wieser A, Geldmacher C, Hoelscher M, Gänzer H, Weiss G, Schmitz D, Drosten C, Prüss H, Wilson I, Kreye J. SARS-CoV-2 Beta variant infection elicits potent lineage-specific and cross-reactive antibodies. Science 2022, 375: eabm5835. PMID: 35076281, PMCID: PMC8939768, DOI: 10.1126/science.abm5835.Peer-Reviewed Original ResearchConceptsCross-reactive antibodiesReceptor-binding domain antibodiesMajor antibody classCOVID-19 patientsSARS-CoV-2Next-generation vaccinesInfection elicitsVaccinated individualsAntibody responseAntibody classAntigenic driftWild-type virusPatientsBeta variantAntibodiesClonotypesDomain antibodiesVaccineMutationsSerum