2023
Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke
Fast L, Temuulen U, Villringer K, Kufner A, Ali H, Siebert E, Huo S, Piper S, Sperber P, Liman T, Endres M, Ritter K. Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke. Frontiers In Neurology 2023, 14: 1114360. PMID: 36895902, PMCID: PMC9990416, DOI: 10.3389/fneur.2023.1114360.Peer-Reviewed Original ResearchMini-Mental State ExaminationClinical outcomesBarthel IndexIschemic strokePrognostic factorsPatient dischargeCognitive functionFunctional recovery outcomesFurther patient careHealth Stroke ScaleEpidemiologic Studies Depression ScaleIschemic stroke patientsStroke ScaleAcute strokeProspective cohortRankin ScaleFunctional recoveryPrognostic featuresStroke patientsModified Telephone InterviewTreatment strategiesDepression ScaleIndividual patientsState ExaminationHealthcare providers
2021
The Dynamic of Extracellular Vesicles in Patients With Subacute Stroke: Results of the “Biomarkers and Perfusion—Training-Induced Changes After Stroke” (BAPTISe) Study
Jödicke R, Huo S, Kränkel N, Piper S, Ebinger M, Landmesser U, Flöel A, Endres M, Nave A. The Dynamic of Extracellular Vesicles in Patients With Subacute Stroke: Results of the “Biomarkers and Perfusion—Training-Induced Changes After Stroke” (BAPTISe) Study. Frontiers In Neurology 2021, 12: 731013. PMID: 34819906, PMCID: PMC8606784, DOI: 10.3389/fneur.2021.731013.Peer-Reviewed Original ResearchBarthel IndexFunctional outcomeCardiovascular eventsSubacute strokeExtracellular vesiclesSubacute ischemic stroke patientsLong-term cardiovascular outcomesWorse Barthel IndexIschemic stroke patientsLower Barthel IndexRecurrent cardiovascular eventsWorse functional outcomeSerial blood samplesLevels of EVsRegression analysisMixed-model regression analysisMixed model regression analysisCardiovascular outcomesIschemic strokeFluorescence-activated cellStroke patientsTrial interventionAerobic trainingClinical trialsLower increase
2020
Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke: PROSCIS-B.
Huo S, Kränkel N, Nave A, Sperber P, Rohmann J, Piper S, Heuschmann P, Landmesser U, Endres M, Siegerink B, Liman T. Endothelial and Leukocyte-Derived Microvesicles and Cardiovascular Risk After Stroke: PROSCIS-B. Neurology 2020, 96: e937-e946. PMID: 33184230, DOI: 10.1212/wnl.0000000000011223.Peer-Reviewed Original ResearchConceptsPlatelet-derived MVsCardiovascular outcomesCause mortalityMyocardial infarctionLong-term cardiovascular outcomesCox proportional hazards modelLeukocyte-derived microvesiclesClass II evidenceWorse cardiovascular outcomesLong-term prognosisKaplan-Meier curvesPlatelet-derived microvesiclesProportional hazards modelRecurrent strokeCardiovascular riskEndothelial dysfunctionIschemic strokeProspective cohortHighest quartileStroke patientsVascular inflammationMild strokeEndothelial microvesiclesLowest quartileHazards model