2023
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Arends C, Liman T, Strzelecka P, Kufner A, Löwe P, Huo S, Stein C, Piper S, Tilgner M, Sperber P, Dimitriou S, Heuschmann P, Hablesreiter R, Harms C, Bullinger L, Weber J, Endres M, Damm F. Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke. Blood 2023, 141: 787-799. PMID: 36441964, DOI: 10.1182/blood.2022017661.Peer-Reviewed Original ResearchConceptsComposite end pointPrimary composite end pointRecurrent vascular eventsVascular eventsIschemic strokeClonal hematopoiesisInterleukin-6Risk factorsHigh-sensitivity C-reactive proteinLarge artery atherosclerosis strokeVascular cell adhesion molecule-1Cell adhesion molecule-1Secondary vascular eventsIncident ischemic strokeMultivariable Cox regressionIndependent risk factorC-reactive proteinRisk of atherosclerosisShorter overall survivalMajor risk factorWhite matter lesionsAdhesion molecule-1Peripheral blood DNAPrecision medicine approachIL-6 receptor
2021
High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke
Scheitz J, Lim J, Broersen L, Ganeshan R, Huo S, Sperber P, Piper S, Heuschmann P, Audebert H, Nolte C, Siegerink B, Endres M, Liman T. High‐Sensitivity Cardiac Troponin T and Recurrent Vascular Events After First Ischemic Stroke. Journal Of The American Heart Association 2021, 10: e018326. PMID: 33982599, PMCID: PMC8200699, DOI: 10.1161/jaha.120.018326.Peer-Reviewed Original ResearchConceptsRecurrent vascular eventsModerate ischemic strokeVascular eventsCardiac troponin TIschemic strokePrimary outcomeHs-cTnTCox proportional hazards regression analysisTroponin THigh-sensitivity cardiac troponin TProportional hazards regression analysisSensitivity cardiac troponin TFirst ischemic strokeCardiac troponin levelsHazards regression analysisHs-cTnT levelsIndividualized risk stratificationBackground Recent evidenceUpper reference limitDose-response relationshipCause deathRecurrent strokeTroponin levelsStudy entryVascular risk
2020
Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke
Rohmann J, Huo S, Sperber P, Piper S, Rosendaal F, Heuschmann P, Endres M, Liman T, Siegerink B. Coagulation factor XII, XI, and VIII activity levels and secondary events after first ischemic stroke. Journal Of Thrombosis And Haemostasis 2020, 18: 3316-3324. PMID: 32935900, DOI: 10.1111/jth.15092.Peer-Reviewed Original ResearchConceptsFirst ischemic strokeIschemic strokeCoagulation factor XIIVascular outcomesHazard ratioRisk factorsActivity levelsFactor XIICox proportional hazards modelIschemic stroke eventsRecurrent vascular eventsWorse vascular outcomesCardiovascular risk factorsIschemic stroke patientsFirst thrombotic eventSecondary eventsProportional hazards modelModerate ischemic stroke patientsFactor activity levelsRecurrent strokeCause mortalityProspective cohortVascular eventsThrombotic eventsStroke events
2019
Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B)
Sperber P, Siegerink B, Huo S, Rohmann J, Piper S, Prüss H, Heuschmann P, Endres M, Liman T. Serum Anti-NMDA (N-Methyl-D-Aspartate)-Receptor Antibodies and Long-Term Clinical Outcome After Stroke (PROSCIS-B). Stroke 2019, 50: 3213-3219. PMID: 31526121, DOI: 10.1161/strokeaha.119.026100.Peer-Reviewed Original ResearchConceptsSecondary vascular eventsFunctional outcomeVascular eventsHigh titersNMDAR1-ABSeronegative patientsSeropositive patientsFirst strokeLong-term clinical outcomesLong-term functional outcomeCombined end pointRecurrent vascular eventsOutcomes of patientsPoor functional outcomeSub-group analysisOutcomes of interestAnti-NMDAAutoimmune encephalitisCardiovascular riskProspective cohortRankin ScaleHazard ratioClinical outcomesNeuroprotective effectsReceptor antibodies