Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury
Major S, Huo S, Lemale C, Siebert E, Milakara D, Woitzik J, Gertz K, Dreier J. Direct electrophysiological evidence that spreading depolarization-induced spreading depression is the pathophysiological correlate of the migraine aura and a review of the spreading depolarization continuum of acute neuronal mass injury. GeroScience 2019, 42: 57-80. PMID: 31820363, PMCID: PMC7031471, DOI: 10.1007/s11357-019-00142-7.Peer-Reviewed Original ResearchConceptsDepression of activityDirect electrophysiological evidenceMigraine auraNeurological deficitsPathophysiological correlatesGray matterMassive glutamate releaseMassive ion translocationTransient ischemic attackFocal neurological deficitsCerebral amyloid angiopathyAneurysmal subarachnoid hemorrhageElectrophysiological evidenceMass injuryBrain gray matterIschemic attackMigraine strokeDendritic beadingAmyloid angiopathyGlutamate releaseSubarachnoid hemorrhageDirect current potentialNeuronal somataClinical distinctionIschemic tissue