1990
RAS gene activation in acute myelogenous leukemia: Analysis by in vitro amplification and dna base sequence determination
Mane S, Meltzer S, Gutheil J, Kapil V, Lee E, Needleman S. RAS gene activation in acute myelogenous leukemia: Analysis by in vitro amplification and dna base sequence determination. Genes Chromosomes And Cancer 1990, 2: 71-77. PMID: 2278967, DOI: 10.1002/gcc.2870020113.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCohort StudiesDNA Mutational AnalysisDNA, NeoplasmExonsGene Expression Regulation, NeoplasticGenes, rasHumansIatrogenic DiseaseLeukemia, Myeloid, AcuteMolecular Sequence DataPolymerase Chain ReactionProspective StudiesProto-Oncogene Proteins p21(ras)Transcriptional ActivationConceptsAcute myeloid leukemia patientsMaryland Cancer CenterMyeloid leukemia patientsAcute myelogenous leukemiaRAS gene activationProspective cohortCancer CenterLeukemia patientsPrecise prevalenceMyelogenous leukemiaNRAS mutationsRAS activationRAS mutationsGene point mutationsBiologic parametersLarger studyHuman cancersPatientsAMLProtooncogene activationExon mutationsActivationCell DNAMutationsPoint mutationsRAS gene product expression in blood and marrow smears of patients with acute leukemia: Importance of fixation
Needleman S, Cimino E, Mane S, Gutheil J, Kapil V, Chana G. RAS gene product expression in blood and marrow smears of patients with acute leukemia: Importance of fixation. Pathology 1990, 22: 77-81. PMID: 2235101, DOI: 10.3109/00313029009063784.Peer-Reviewed Original ResearchMeSH KeywordsBone MarrowFixativesHumansImmunoenzyme TechniquesLeukemia, Myeloid, AcuteProto-Oncogene Proteins p21(ras)ConceptsAcute non-lymphoblastic leukemiaP21 expressionAcute leukemiaMarrow aspiratesNon-lymphoblastic leukemiaNon-malignant diseasesHigh p21 expressionRas p21 expressionHistologic anaplasiaMost patientsRegional lymphLeukemic blastsProstate cancerBreast cancerGene product expressionPlasma cellsMarrow smearsNormal volunteersBlast cellsPatientsMyeloid cellsCodon 12Importance of fixationBlood smearsHuman malignancies
1989
Immunoprecipitation of cell lysates with RAP-5 does not specifically detect ras oncogene product p21
Gutheil J, Mane S, Kapil V, Needleman S. Immunoprecipitation of cell lysates with RAP-5 does not specifically detect ras oncogene product p21. Human Pathology 1989, 20: 1176-1180. PMID: 2687155, DOI: 10.1016/s0046-8177(89)80008-5.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalBreast NeoplasmsCell LinePrecipitin TestsProto-Oncogene ProteinsProto-Oncogene Proteins p21(ras)