The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage
Nair S, Ramaswamy PA, Ghosh S, Joshi DC, Pathak N, Siddiqui I, Sharma P, Hasnain SE, Mande SC, Mukhopadhyay S. The PPE18 of Mycobacterium tuberculosis Interacts with TLR2 and Activates IL-10 Induction in Macrophage. The Journal Of Immunology 2009, 183: 6269-6281. PMID: 19880448, DOI: 10.4049/jimmunol.0901367.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, BacterialBacterial ProteinsCell LineCytokinesExtracellular Signal-Regulated MAP KinasesHumansInterleukin-10LipopolysaccharidesMacrophage ActivationMacrophagesMAP Kinase Kinase 4MonocytesMycobacterium tuberculosisP38 Mitogen-Activated Protein KinasesRecombinant ProteinsSignal TransductionToll-Like Receptor 2TuberculosisConceptsIL-10 inductionIL-10Proline-glutamic acidTh2-type responseIL-10 productionAnti-inflammatory responseMycobacterium tuberculosis strainsTHP-1 macrophagesPPE18 proteinInfected macrophagesTuberculosis strainsTLR2PPE18Synthetic lipopeptideMycobacterium tuberculosisMacrophagesMycobacterium tuberculosis interactsERK 1/2M. smegmatis strainPathophysiological functionsP38 MAPKType responseSilico docking analysisSustained activationPoor level