2018
A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco‐deprived and ‐satiated smokers
Roberts W, Verplaetse TL, Moore KE, Oberleitner LM, McKee SA. A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco‐deprived and ‐satiated smokers. Human Psychopharmacology Clinical And Experimental 2018, 33: e2660. PMID: 29878501, PMCID: PMC5995328, DOI: 10.1002/hup.2660.Peer-Reviewed Original ResearchConceptsContinuous performance taskInhibitory controlCognitive functioningPerformance taskTobacco withdrawalEffects of doxazosinSustained attentionCognitive performanceWithdrawal symptomsCognitive AssessmentSmoking outcomesMost measuresSelf-reported withdrawal symptomsReaction timeTaskParticipantsFunctioningPredrug levelsΑ1 antagonistTitration periodGreater improvementDoxazosinSmokingSymptomsPreliminary investigation
2015
Gender Differences in Medication Use and Cigarette Smoking Cessation: Results From the International Tobacco Control Four Country Survey
Smith PH, Kasza KA, Hyland A, Fong GT, Borland R, Brady K, Carpenter MJ, Hartwell K, Cummings KM, McKee SA. Gender Differences in Medication Use and Cigarette Smoking Cessation: Results From the International Tobacco Control Four Country Survey. Nicotine & Tobacco Research 2015, 17: 463-472. PMID: 25762757, PMCID: PMC4402353, DOI: 10.1093/ntr/ntu212.Peer-Reviewed Original ResearchConceptsMedication useInternational Tobacco Control Four Country SurveySmoking cessationFour Country SurveyQuit attemptsCessation medication useCigarette smoking cessationGender differencesAdjusted modelingQuit attemptersNicotine patchSuccessful quittingSubsample of smokersAdult smokersLower oddsCountry SurveyWomenSelf-selected useCessationSmokersSCM useMenWaves 2006Survey wavesVareniclineTargeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence
Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence. Nicotine & Tobacco Research 2015, 17: 486-495. PMID: 25762760, PMCID: PMC4432402, DOI: 10.1093/ntr/ntu280.Peer-Reviewed Original ResearchMeSH KeywordsFemaleGender IdentityHumansMaleNicotineReceptors, AndrogenSmoking CessationSmoking PreventionSubstance Withdrawal SyndromeConceptsSmoking cessationNoradrenergic systemClinical evidenceTobacco dependenceNoradrenergic activityMedication developmentPoor smoking cessation outcomesCause of morbiditySmoking cessation outcomesStress reactivitySex-specific mechanismsLower quit ratesNicotine-related reinforcementCurrent medicationsMedication effectivenessNicotine reinforcementCessation outcomesNoradrenergic agentsQuit ratesTreatment strategiesTobacco useNoradrenergic compoundsSmoking outcomesTreatment developmentWomenSystematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation
Weinberger AH, Smith PH, Allen SS, Cosgrove KP, Saladin ME, Gray KM, Mazure CM, Wetherington CL, McKee SA. Systematic and Meta-Analytic Review of Research Examining the Impact of Menstrual Cycle Phase and Ovarian Hormones on Smoking and Cessation. Nicotine & Tobacco Research 2015, 17: 407-421. PMID: 25762750, PMCID: PMC4429881, DOI: 10.1093/ntr/ntu249.Peer-Reviewed Original ResearchMeSH KeywordsAdultFemaleFollicular PhaseGender IdentityHumansLuteal PhaseMenstrual CycleSmokingSmoking CessationSubstance Withdrawal SyndromeWomen's HealthConceptsMenstrual cycle phaseHormone levelsOvarian hormonesLuteal phaseSmoking behaviorSearch termsOvarian hormone levelsMenstrual phase effectsCessation-related behaviorsTiming of interventionNegative subjective effectsMenstrual cycle effectsProgesterone administrationFollicular phaseMedication responseQuit ratesTonic cravingInclusion criteriaMenstrual phaseNonsignificant trendSmoking outcomesCycle phaseSmokingSystematic reviewGreater tonic
2014
Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking
Wilson SJ, Delgado MR, McKee SA, Grigson PS, MacLean RR, Nichols TT, Henry SL. Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking. Cognitive, Affective, & Behavioral Neuroscience 2014, 14: 1196-1207. PMID: 24777394, PMCID: PMC4213351, DOI: 10.3758/s13415-014-0285-8.Peer-Reviewed Original ResearchConceptsNicotine-deprived smokersIndividual differencesNondrug rewardsMonetary outcomesVentral striatumReward-related brain activityMeaningful individual differencesFunctional magnetic resonance imagingReward-motivated behaviorsLarge individual differencesVentral striatal responsePoor smoking cessation outcomesSmoking cessation outcomesNondrug incentivesReward devaluationNeural responsesStriatal responsesNeurobiological mechanismsBrain activityNeurobiological responsesCessation outcomesRewardMonetary reinforcementIndividual variabilityClinical implications
2012
Developing and Validating a Human Laboratory Model to Screen Medications for Smoking Cessation
McKee SA, Weinberger AH, Shi J, Tetrault J, Coppola S. Developing and Validating a Human Laboratory Model to Screen Medications for Smoking Cessation. Nicotine & Tobacco Research 2012, 14: 1362-1371. PMID: 22492085, PMCID: PMC3482010, DOI: 10.1093/ntr/nts090.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectFemaleHumansMaleMiddle AgedSelf AdministrationSmokingSmoking CessationSubstance Withdrawal SyndromeTobacco Use Cessation DevicesTreatment OutcomeYoung AdultConceptsSubsequent ad libitum smokingSmoking cessation medicationsAd libitum smokingCessation medicationsNicotine deprivationSmoking cessationNovel smoking cessation medicationsRatings of cravingSmoking lapse behaviorHuman laboratory modelSecondary outcomesClinical efficacyClinical findingsFirst cigaretteMedication effectsSmokingMedication developmentCigarette effectsMedicationsLapse behaviorSmoking lapseTranslational toolScreen medicationsMonetary reinforcementTranslational workSex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers
Cosgrove KP, Esterlis I, McKee SA, Bois F, Seibyl JP, Mazure CM, Krishnan-Sarin S, Staley JK, Picciotto MR, O’Malley S. Sex Differences in Availability of β2*-Nicotinic Acetylcholine Receptors in Recently Abstinent Tobacco Smokers. JAMA Psychiatry 2012, 69: 418-427. PMID: 22474108, PMCID: PMC3508698, DOI: 10.1001/archgenpsychiatry.2011.1465.Peer-Reviewed Original ResearchMeSH KeywordsAdultAzetidinesBehavior, AddictiveBrainDepressionEstradiolFemaleFunctional NeuroimagingHumansIodine RadioisotopesMaleNicotinic AntagonistsProgesteronePyridinesRadioligand AssayReceptors, NicotinicSex CharacteristicsSmokingSubstance Withdrawal SyndromeTomography, Emission-Computed, Single-PhotonConceptsNAChR availabilityFemale smokersTobacco smokersNicotinic acetylcholine receptorsFemale nonsmokersProgesterone levelsAcetylcholine receptorsFemale sex steroid hormonesSex differencesSex steroid hormone levelsAbstinent tobacco smokersSex-matched nonsmokersTobacco smoking effectsMagnetic resonance imaging studyAge-matched malesEquilibrium distribution volumeEffects of nicotineSex steroid hormonesSteroid hormone levelsUnderlying neurochemical mechanismsResonance imaging studySingle photon emissionDays of abstinenceIA SPECTNicotine therapySex‐specific differences in GABAA‐benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving
Esterlis I, McKee SA, Kirk K, Lee D, Bois F, Stiklus SM, Seibyl JP, Krishnan‐Sarin S, O'Malley SS, Staley JK, Cosgrove KP. Sex‐specific differences in GABAA‐benzodiazepine receptor availability: relationship with sensitivity to pain and tobacco smoking craving. Addiction Biology 2012, 18: 370-378. PMID: 22353491, PMCID: PMC3378766, DOI: 10.1111/j.1369-1600.2011.00403.x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAffective SymptomsAnalysis of VarianceAnimalsBrainFemaleFlumazenilGABA ModulatorsHumansMaleMiddle AgedNicotinePain PerceptionReceptors, GABA-ASex CharacteristicsSmoking CessationSubstance Withdrawal SyndromeTobacco Use DisorderTomography, Emission-Computed, Single-PhotonYoung AdultConceptsMale smokersFemale smokersPain sensitivitySmoking interactionSmoking cravingBrain GABA levelsTobacco smoking behaviorSingle photon emissionPain symptomsLast cigaretteSmoking cessationGABA levelsSex-specific differencesTobacco smokeCigarette cravingNicotine dependenceBenzodiazepine receptorsSmokersSmoking behaviorReceptor availabilityBrain regionsCravingSex-specific regulationSignificant differencesSex differences
2011
Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers
Herman AI, Waters AJ, McKee SA, Sofuoglu M. Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers. Psychopharmacology 2011, 220: 611-617. PMID: 21947318, PMCID: PMC3654651, DOI: 10.1007/s00213-011-2507-x.Peer-Reviewed Original ResearchConceptsPregabalin treatmentSmoking behaviorWithdrawal symptomsTreatment periodAd lib smoking behaviorCognitive performanceEffect of pregabalinTobacco withdrawal symptomsDays of treatmentPregabalin effectCrossover studyWashout periodNicotine withdrawalGABA neurotransmissionNicotine rewardSmoking periodTobacco withdrawalAbstinent smokersBrain glutamateClinical studiesNicotine addictionSmokersPregabalinConclusionsThese findingsGABA analogues
2010
Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The International Journal Of Neuropsychopharmacology 2010, 14: 389-398. PMID: 21029513, PMCID: PMC3510008, DOI: 10.1017/s1461145710001227.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, InhalationAdultBehavior, AddictiveFemaleHumansMaleMiddle AgedNicotineNicotinic AgonistsReceptors, NicotinicSmokingSmoking CessationSubstance Withdrawal SyndromeYoung AdultConceptsNicotine inhalerWithdrawal symptomsReceptor occupancyTobacco smokingLow nicotine cigarettesAdministration of nicotineHigh receptor occupancyDoses of nicotineNicotinic acetylcholine receptorsInhaler useTobacco smokersBaseline scanRegular cigarettesInhalerConstant infusionAcetylcholine receptorsSPECT studiesCigarettesSymptomsBeta 2Significant decreaseNicotineSignificant differencesSmokingNAChRsBeta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers
Cosgrove KP, Esterlis I, McKee S, Bois F, Alagille D, Tamagnan GD, Seibyl JP, Krishnan-Sarin S, Staley JK. Beta2* nicotinic acetylcholine receptors modulate pain sensitivity in acutely abstinent tobacco smokers. Nicotine & Tobacco Research 2010, 12: 535-539. PMID: 20371741, PMCID: PMC2861889, DOI: 10.1093/ntr/ntq040.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPainReceptors, NicotinicSmokingSubstance Withdrawal SyndromeYoung AdultConceptsPain sensitivityCold pressor taskTobacco smokersNicotinic acetylcholine receptorsPain toleranceAcute withdrawalSmoking abstinenceOccipital cortexAnterior cingulateAcetylcholine receptorsAbstinent tobacco smokersHuman tobacco smokersTobacco smoking abstinenceTomography brain imagingSingle photon emissionIA SPECTIA-85380Smoking withdrawalAntinociceptive effectPainful stimuliAcute abstinencePercent changeSimilar associationSmokersBrain imaging
2009
Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders
Weinberger AH, Desai RA, McKee SA. Nicotine withdrawal in U.S. smokers with current mood, anxiety, alcohol use, and substance use disorders. Drug And Alcohol Dependence 2009, 108: 7-12. PMID: 20006451, PMCID: PMC2835820, DOI: 10.1016/j.drugalcdep.2009.11.004.Peer-Reviewed Original ResearchConceptsSubstance use disordersCurrent mood disorderAlcohol use disorderCo-morbid psychiatric disordersTobacco withdrawal symptomsWithdrawal symptomsPsychiatric disordersMood disordersUse disordersNicotine withdrawalAnxiety disordersCurrent Axis I disordersCurrent daily smokersCurrent psychiatric disorderAxis I DisordersMore withdrawal symptomsWithdrawal-related symptomsNational Epidemiologic SurveyLogistic regression modelsPrevent relapseDaily smokersI disordersU.S. smokersAxis ICurrent disorderEffects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study
McKee SA, Weinberger AH, Harrison EL, Coppola S, George TP. Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study. Schizophrenia Research 2009, 115: 317-324. PMID: 19700263, PMCID: PMC2784178, DOI: 10.1016/j.schres.2009.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior, AddictiveDouble-Blind MethodFemaleHumansMaleMecamylamineMiddle AgedNeuropsychological TestsNicotinic AntagonistsReaction TimeSchizophreniaSelf AdministrationSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderYoung AdultConceptsAd lib smoking behaviorNicotine levelsSmoking behaviorControl smokersSmoking topographyNicotinic receptor antagonist mecamylamineNicotinic acetylcholine receptor antagonistHealthy control smokersHigh-affinity nAChRsIntensity of smokingAd lib smokingEffects of mecamylamineNumber of cigarettesPlacebo-controlled designAcetylcholine receptor antagonistNicotine exposureAntagonist mecamylamineCompensatory smokingReceptor antagonistSmoking intensityMecamylamineSmokersSmokingSchizophreniaPreliminary studyNicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention
Harrison EL, Coppola S, McKee SA. Nicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention. Experimental And Clinical Psychopharmacology 2009, 17: 91-98. PMID: 19331485, PMCID: PMC2863308, DOI: 10.1037/a0015657.Peer-Reviewed Original ResearchConceptsCognitive processingNicotine deprivationImpulsive smokersTrait impulsivityGo/No-Go taskBarratt Impulsiveness ScaleCognitive tasksInhibitory controlPerformance decrementsImpulsiveness ScaleTask IISubjects designImpulsivityGreater impairmentDaily smokersReaction timeDeprivation conditionsMixed model regression analysisTaskProcessingRelapse riskImpairmentSignificant deprivationImpulsivenessDeprivationGender Differences in Associations between Lifetime Alcohol, Depression, Panic Disorder, and Posttraumatic Stress Disorder and Tobacco Withdrawal
Weinberger AH, Maciejewski PK, McKee SA, Reutenauer EL, Mazure CM. Gender Differences in Associations between Lifetime Alcohol, Depression, Panic Disorder, and Posttraumatic Stress Disorder and Tobacco Withdrawal. American Journal On Addictions 2009, 18: 140-147. PMID: 19283566, PMCID: PMC2874459, DOI: 10.1080/10550490802544888.Peer-Reviewed Original ResearchConceptsAlcohol abuse/dependenceAbuse/dependenceMajor depressionWithdrawal symptomsPsychiatric statusSmoking relapsePanic disorderIndices of withdrawalStrong associationSmoking cessation interventionNational Comorbidity SurveyPosttraumatic stress disorderGender-specific effectsCessation interventionsNicotine withdrawalTobacco withdrawalRetrospective dataStress disorderLifetime alcoholLonger durationDepressionWithdrawalDisordersRelapseMultiple regression analysis
2008
Correspondence of Interactive Voice Response (IVR) Reports of Nicotine Withdrawal, Craving, and Negative Mood with Questionnaire Ratings
Toll BA, Cooney JL, McKee SA, O'Malley SS, Cooney NL. Correspondence of Interactive Voice Response (IVR) Reports of Nicotine Withdrawal, Craving, and Negative Mood with Questionnaire Ratings. Nicotine & Tobacco Research 2008, 10: 1057-1064. PMID: 18584469, PMCID: PMC2791461, DOI: 10.1080/14622200802097498.Peer-Reviewed Original ResearchConceptsNicotine withdrawalDepressive symptomsSmoking cessation trialCessation trialDaily smokersInteractive voice response systemVoice response systemDaily assessmentCravingWeeksNegative moodWithdrawalSymptomsPaper questionnaireQuestionnaire ratingsReportFuture studiesQuestionnaireIVR systemMoodDaysSample sizeDaily reportsSmokersSmokingRelationship of perceived risks of smoking cessation to symptoms of withdrawal, craving, and depression during short-term smoking abstinence
Weinberger AH, Krishnan-Sarin S, Mazure CM, McKee SA. Relationship of perceived risks of smoking cessation to symptoms of withdrawal, craving, and depression during short-term smoking abstinence. Addictive Behaviors 2008, 33: 960-963. PMID: 18384974, PMCID: PMC2442160, DOI: 10.1016/j.addbeh.2008.02.013.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultDepressive DisorderFemaleHumansMaleMiddle AgedRisk FactorsSex FactorsSmokingSmoking CessationSubstance Withdrawal SyndromeTime FactorsTobacco Use DisorderConceptsShort-term smoking abstinenceShort-term abstinenceSelf-reported experiencesExperienced withdrawal symptomsWithdrawal symptomsBehavioral interventionsSmoking cessationContingency managementCravingRisk beliefsSmoking abstinenceDaily smokersHigh levelsRelationship of riskRisk perceptionNicotine dependenceAbstinenceParticipantsCurrent studySymptoms of withdrawalDepressionBaseline smokingRisk groupsSymptomsRelationship
2007
Confirmatory Factor Analysis of the Minnesota Nicotine Withdrawal Scale
Toll BA, O’Malley S, McKee SA, Salovey P, Krishnan-Sarin S. Confirmatory Factor Analysis of the Minnesota Nicotine Withdrawal Scale. Psychology Of Addictive Behaviors 2007, 21: 216-225. PMID: 17563141, PMCID: PMC2527730, DOI: 10.1037/0893-164x.21.2.216.Peer-Reviewed Original ResearchMeSH KeywordsAdultFactor Analysis, StatisticalFemaleHumansMaleMiddle AgedMinnesotaNicotineSmoking CessationSubstance Withdrawal SyndromeSyndromeTobacco Use DisorderConceptsMinnesota Nicotine Withdrawal ScaleWithdrawal ScaleTotal scorePoorer smoking outcomesClinical studiesClinical research samplesSmoking outcomesChange scoresStudy sampleConfirmatory factor analysisGood internal consistency estimatesScoresFactor analysisFuture investigatorsSmokersSyndromeSymptomsFactor scoresFactor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit.
Toll BA, McKee SA, Martin DJ, Jatlow P, O'Malley SS. Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit. Nicotine & Tobacco Research 2007, 9: 597-605. PMID: 17454716, PMCID: PMC2527736, DOI: 10.1080/14622200701239662.Peer-Reviewed Original ResearchConceptsMedication Adherence QuestionnaireCigarette smokersNicotine patchAdherence QuestionnaireMedication adherenceNicotine patch useSmoking cessation outcomesPill-taking behaviorSample of smokersDrug plasma levelsBrief screening toolNonadherence factorsMedication useUnintentional nonadherencePlasma levelsCessation outcomesClinical trialsTreatment outcomesDrug levelsPredictive validitySmokersMAQ scoresNonadherenceScreening toolFactor 1Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study
Toll BA, Schepis TS, O’Malley S, McKee SA, Krishnan-Sarin S. Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study. Drug And Alcohol Dependence 2007, 89: 302-305. PMID: 17320313, PMCID: PMC2475673, DOI: 10.1016/j.drugalcdep.2007.01.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAgedAntidepressive Agents, Second-GenerationBehavior TherapyBupropionCircadian RhythmDelayed-Action PreparationsFemaleHumansMaleMiddle AgedMotivationNicotineOutcome Assessment, Health CarePrognosisSecondary PreventionSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderConceptsFirst cigaretteSmoking relapseEnd of treatmentCessation treatment outcomeInitial cigaretteWithdrawal symptomsClinical trialsQuit dayTreatment outcomesNovel predictorRelapseCigarettesPreliminary studyTime pointsGreater decreaseCravingSubjective responsesSubjective reactivityDaysFuture studiesSignificant changesWithdrawalPredictorsResponseBupropion