2014
A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation
McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten A, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal Of Psychopharmacology 2014, 29: 300-311. PMID: 25516371, PMCID: PMC4376109, DOI: 10.1177/0269881114562091.Peer-Reviewed Original ResearchConceptsPlacebo-treated subjectsFunctional magnetic resonance imagingCentral noradrenergic pathwaysPrefrontal cognitive dysfunctionSystolic blood pressureClinical outcome dataAd libitum smokingNovel translational approachStress-induced reinstatementMagnetic resonance imagingNicotine-deprived smokersBlood pressureNoradrenergic pathwaysAgonist guanfacineCognitive dysfunctionTreatment periodTobacco cravingQuit attemptsOutcome dataSmokingComplete abstinenceCortisol levelsTranslational investigationsCigarette useGuanfacine
2011
Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers
Herman AI, Waters AJ, McKee SA, Sofuoglu M. Effects of pregabalin on smoking behavior, withdrawal symptoms, and cognitive performance in smokers. Psychopharmacology 2011, 220: 611-617. PMID: 21947318, PMCID: PMC3654651, DOI: 10.1007/s00213-011-2507-x.Peer-Reviewed Original ResearchConceptsPregabalin treatmentSmoking behaviorWithdrawal symptomsTreatment periodAd lib smoking behaviorCognitive performanceEffect of pregabalinTobacco withdrawal symptomsDays of treatmentPregabalin effectCrossover studyWashout periodNicotine withdrawalGABA neurotransmissionNicotine rewardSmoking periodTobacco withdrawalAbstinent smokersBrain glutamateClinical studiesNicotine addictionSmokersPregabalinConclusionsThese findingsGABA analogues
2010
Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion
Mazure CM, Toll B, McKee SA, Wu R, O’Malley S. Menstrual cycle phase at quit date and smoking abstinence at 6 weeks in an open label trial of bupropion. Drug And Alcohol Dependence 2010, 114: 68-72. PMID: 20832955, PMCID: PMC3016455, DOI: 10.1016/j.drugalcdep.2010.07.024.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseQuit datePoint prevalence abstinencePremenopausal womenBupropion SRFollicular phaseLuteal phaseAbsence of pharmacotherapySustained release bupropionOpen-label trialCycle phaseMechanism of actionRelease bupropionLabel trialNicotine replacementCessation interventionsOpen trialTreatment completionCessation outcomesContinuous abstinenceQuit dayGonadal hormonesTreatment periodAbstinence outcomesQuit attempts
2008
Risk factors for treatment failure in smokers: Relationship to alcohol use and to lifetime history of an alcohol use disorder
Leeman RF, McKee SA, Toll BA, Krishnan-Sarin S, Cooney JL, Makuch RW, O'Malley SS. Risk factors for treatment failure in smokers: Relationship to alcohol use and to lifetime history of an alcohol use disorder. Nicotine & Tobacco Research 2008, 10: 1793-1809. PMID: 19023831, PMCID: PMC2764010, DOI: 10.1080/14622200802443742.Peer-Reviewed Original ResearchConceptsHeavy drinking daysAlcohol use disorderAUD historyCessation relapseUse disordersDrinking daysModerate drinkingAlcohol useSustained-release bupropionLifetime alcohol use disorderModerate alcohol usersRandomized clinical trialsAlcohol use categoriesProbability of smokingSmoking cessation failureTreatment failureAlcohol use levelsRisk factorsClinical trialsHazardous patternsTreatment periodHazardous drinkersAbstinent daysCessation failureAlcohol usersA brief 7-day estimate of alcohol consumption for use in smoking cessation clinical trials
Toll BA, Leeman RF, McKee SA, O'Malley SS. A brief 7-day estimate of alcohol consumption for use in smoking cessation clinical trials. Addictive Behaviors 2008, 33: 1606-1609. PMID: 18722721, PMCID: PMC2577001, DOI: 10.1016/j.addbeh.2008.07.007.Peer-Reviewed Original ResearchConceptsCessation clinical trialHeavy drinking daysNumber of drinksClinical trialsDays abstinentDrinking daysTimeline FollowbackSmoking cessation clinical trialAlcohol useTreatment periodSmoking relapseAlcohol consumptionCessation studyTotal abstinenceBaselineDrinking dataTime burdenAbstinentAbstinenceTrialsDaysTreatmentMost studiesLong periodLonger time window