2018
Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking
Roberts W, Ralevski E, Verplaetse TL, McKee SA, Petrakis IL. Tobacco use during a clinical trial of mecamylamine for alcohol dependence: Medication effects on smoking and associations with reductions in drinking. Journal Of Substance Use And Addiction Treatment 2018, 94: 91-96. PMID: 30243424, PMCID: PMC6154389, DOI: 10.1016/j.jsat.2018.08.015.Peer-Reviewed Original ResearchConceptsAlcohol use disorderClinical trialsSmoking outcomesNicotinic acetylcholine receptor antagonistAlcohol useHigh-dependence smokersEffects of mecamylamineSubgroups of smokersAcetylcholine receptor antagonistHigh tobacco dependencePlacebo groupMedication conditionReceptor antagonistMedication effectsTobacco dependenceTobacco useTreatment respondersMecamylamineSmokingTreatment phaseUse disordersAlcohol dependenceSmokersTrialsSignificant differences
2016
Targeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings
Verplaetse TL, McKee SA. Targeting the Brain Stress Systems for the Treatment of Tobacco/Nicotine Dependence: Translating Preclinical and Clinical Findings. Current Addiction Reports 2016, 3: 314-322. PMID: 31275802, PMCID: PMC6609087, DOI: 10.1007/s40429-016-0115-x.Peer-Reviewed Original ResearchBrain stress systemsTobacco useNoradrenergic systemTreatment strategiesCorticotropin-releasing factor (CRF) systemTobacco/nicotine dependenceMajority of smokersNicotine-induced activationPotential treatment strategySmoking-related outcomesNicotine-motivated behaviorsLong-term abstinenceStress systemClinical findingsAdrenal axisTobacco dependencePreventable mortalityClinical investigationNicotine dependenceRecent FindingsOneTherapeutic benefitPharmacological agentsCRF systemDrug AdministrationSummaryThis review
2015
Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence
Verplaetse TL, Weinberger AH, Smith PH, Cosgrove KP, Mineur YS, Picciotto MR, Mazure CM, McKee SA. Targeting the Noradrenergic System for Gender-Sensitive Medication Development for Tobacco Dependence. Nicotine & Tobacco Research 2015, 17: 486-495. PMID: 25762760, PMCID: PMC4432402, DOI: 10.1093/ntr/ntu280.Peer-Reviewed Original ResearchConceptsSmoking cessationNoradrenergic systemClinical evidenceTobacco dependenceNoradrenergic activityMedication developmentPoor smoking cessation outcomesCause of morbiditySmoking cessation outcomesStress reactivitySex-specific mechanismsLower quit ratesNicotine-related reinforcementCurrent medicationsMedication effectivenessNicotine reinforcementCessation outcomesNoradrenergic agentsQuit ratesTreatment strategiesTobacco useNoradrenergic compoundsSmoking outcomesTreatment developmentWomen
2009
Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers
McKee SA, Harrison EL, O'Malley SS, Krishnan-Sarin S, Shi J, Tetrault JM, Picciotto MR, Petrakis IL, Estevez N, Balchunas E. Varenicline Reduces Alcohol Self-Administration in Heavy-Drinking Smokers. Biological Psychiatry 2009, 66: 185-190. PMID: 19249750, PMCID: PMC2863311, DOI: 10.1016/j.biopsych.2009.01.029.Peer-Reviewed Original ResearchConceptsHeavy drinking smokersSelf-administration periodAlcohol consumptionPartial nicotinic agonistPlacebo-controlled investigationEffects of vareniclineReduced ethanol intakeAlcohol Self-AdministrationAlcohol use disorderNicotinic acetylcholine receptorsMedication pretreatmentAdverse eventsNumber of drinksPreclinical evidenceAdditional drinkEthanol intakeTobacco dependenceDaily smokersPriming doseVareniclineComorbid disordersNicotinic agonistsUse disordersPriming drinkPotential treatmentExperimenting and daily smokers: Episodic patterns of alcohol and cigarette use
Harrison EL, Hinson RE, McKee SA. Experimenting and daily smokers: Episodic patterns of alcohol and cigarette use. Addictive Behaviors 2009, 34: 484-486. PMID: 19176271, PMCID: PMC2865434, DOI: 10.1016/j.addbeh.2008.12.013.Peer-Reviewed Original ResearchConceptsCigarette useEpisodic patternPatterns of alcoholBinge levelsConsumption of drinksSmoking historyCigarette smokingTobacco dependenceDaily smokersNicotine dependenceSmoking episodesConcurrent alcoholSmokersSmokingMore drinksAlcohol useGroup differencesDrinksTypical drinkingDrinkingTotal numberHoursSelf-reported pleasureCigarettesCollege-age sample