Featured Publications
Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV
Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 2018, 3: e121718. PMID: 30232286, PMCID: PMC6237230, DOI: 10.1172/jci.insight.121718.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidHIV infectionImmune activationAntiretroviral therapyNeuronal injuryCentral nervous system immune activationLong-term suppressive antiretroviral therapySingle-cell RNA sequencingCNS immune activationDisease-associated microgliaSuppressive antiretroviral therapyImmune cell subsetsMicroglia-like cellsGene expression signaturesNeuronal damageNeuroinflammatory diseasesRNA sequencingCell subsetsCNS cellsNeurological conditionsRare subsetNeurocognitive impairmentMyeloid cellsCellular subsetsInfection
2022
2348. Distinct cerebrospinal fluid immune proteins mark neurosyphilis
Catalano A, Yoon J, Farhadian S, Fertuzinhos S, Gisslen M, Zetterberg H, Marra C, Walsh H. 2348. Distinct cerebrospinal fluid immune proteins mark neurosyphilis. Open Forum Infectious Diseases 2022, 9: ofac492.155. DOI: 10.1093/ofid/ofac492.155.Peer-Reviewed Original ResearchHIV statusImmune responseBCA-1/CXCL13Macrophage/microglial activationIP-10/CXCL10IL-8/CXCL8CNS immune responseNeuronal injury markersNon-NS groupPotential CSF biomarkersMIG/CXCL9Date of enrollmentHigh-sensitivity ELISAWilcoxon rank sum testSpecific immune pathwaysMultiple comparisonsRank sum testRace/ethnicityCNS inflammationMicroglial activationCSF WBCElevated markersInjury markersNeuronal damageAsymptomatic disease