Featured Publications
Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV
Farhadian SF, Mehta SS, Zografou C, Robertson K, Price RW, Pappalardo J, Chiarella J, Hafler DA, Spudich SS. Single-cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV. JCI Insight 2018, 3: e121718. PMID: 30232286, PMCID: PMC6237230, DOI: 10.1172/jci.insight.121718.Peer-Reviewed Original ResearchConceptsCerebrospinal fluidHIV infectionImmune activationAntiretroviral therapyNeuronal injuryCentral nervous system immune activationLong-term suppressive antiretroviral therapySingle-cell RNA sequencingCNS immune activationDisease-associated microgliaSuppressive antiretroviral therapyImmune cell subsetsMicroglia-like cellsGene expression signaturesNeuronal damageNeuroinflammatory diseasesRNA sequencingCell subsetsCNS cellsNeurological conditionsRare subsetNeurocognitive impairmentMyeloid cellsCellular subsetsInfection
2024
Epigenetic Changes in Cerebrospinal Fluid and Blood of People with Neurosyphilis
Mostaghimi D, Mehta S, Yoon J, Kosana P, Marra C, Corley M, Farhadian S. Epigenetic Changes in Cerebrospinal Fluid and Blood of People with Neurosyphilis. The Journal Of Infectious Diseases 2024, jiae476. PMID: 39356164, DOI: 10.1093/infdis/jiae476.Peer-Reviewed Original ResearchPeripheral blood mononuclear cellsCerebrospinal fluidRNA expression changesEpigenetic changesExpression changesBlood mononuclear cellsDifferentially methylated sitesDNA methylation profilesInsulin-responsive pathwaysAntibiotic treatmentImmune cellsB cellsMononuclear cellsMethylation changesDNA methylationMethylation profilesMatched controlsBacterial infectionsNon-NENeurosyphilisBlood of peopleInfectionRNANS
2017
Neurological Complications of HIV Infection
Farhadian S, Patel P, Spudich S. Neurological Complications of HIV Infection. Current Infectious Disease Reports 2017, 19: 50. PMID: 29164407, PMCID: PMC7456329, DOI: 10.1007/s11908-017-0606-5.BooksCombination antiretroviral therapyHIV infectionSuppressive combination antiretroviral therapyChronic HIV infectionPathogenesis of HANDPurpose of ReviewHIVHIV-associated dementiaNeurofilament light chainAntiretroviral therapyCNS infectionNeurological complicationsNeurological outcomeHIV diseaseAsymptomatic individualsMonocyte activityBody of evidenceNeurocognitive disordersPreventive strategiesMultifactorial causesCellular injuryMild formInfectionHIVLight chainRecent studies