2348. Distinct cerebrospinal fluid immune proteins mark neurosyphilis
Catalano A, Yoon J, Farhadian S, Fertuzinhos S, Gisslen M, Zetterberg H, Marra C, Walsh H. 2348. Distinct cerebrospinal fluid immune proteins mark neurosyphilis. Open Forum Infectious Diseases 2022, 9: ofac492.155. DOI: 10.1093/ofid/ofac492.155.Peer-Reviewed Original ResearchHIV statusImmune responseBCA-1/CXCL13Macrophage/microglial activationIP-10/CXCL10IL-8/CXCL8CNS immune responseNeuronal injury markersNon-NS groupPotential CSF biomarkersMIG/CXCL9Date of enrollmentHigh-sensitivity ELISAWilcoxon rank sum testSpecific immune pathwaysMultiple comparisonsRank sum testRace/ethnicityCNS inflammationMicroglial activationCSF WBCElevated markersInjury markersNeuronal damageAsymptomatic disease