Featured Publications
Emerging Single-cell Approaches to Understand HIV in the Central Nervous System
Corley MJ, Farhadian SF. Emerging Single-cell Approaches to Understand HIV in the Central Nervous System. Current HIV/AIDS Reports 2021, 19: 113-120. PMID: 34822063, PMCID: PMC8613726, DOI: 10.1007/s11904-021-00586-7.Peer-Reviewed Original ResearchConceptsCentral nervous systemSingle-cell sequencing methodsSingle-cell approachesStudy of genomesSingle-cell technologiesSingle-cell analysisSingle-cell levelSingle-cell studiesNervous systemMolecular identitySequencing methodsRare infected cellsViral establishmentCentral nervous system tissueInfected cellsNervous system tissueAutopsy brainsCNS reservoirsCSF cellsHIV StudyHIVTranslational studiesCNS perturbationsCNS studiesTissue compartments
2024
Neurosyphilis is characterized by a compartmentalized and robust neuroimmune response but not by neuronal injury
Catalano A, Yoon J, Fertuzinhos S, Reisert H, Walsh H, Kosana P, Wilson M, Gisslen M, Zetterberg H, Marra C, Farhadian S. Neurosyphilis is characterized by a compartmentalized and robust neuroimmune response but not by neuronal injury. Med 2024, 5: 321-334.e3. PMID: 38513660, PMCID: PMC11216317, DOI: 10.1016/j.medj.2024.02.005.Peer-Reviewed Original ResearchMarker of neuronal injuryNeuronal injuryNeurological symptomsWhite blood cell count <Immune responsePresence of neurological symptomsNeuroinflammatory diseasesCell count <CSF-VDRL testPlasma reagin titerCNS immune responsesCNS-specific immune responseImmune cell activationCSF inflammatory responseCSF cellsNeurosyphilis casesAsymptomatic neurosyphilisCSF neopterinImmune profileNeuroimmune responseHIV statusNational Institutes of HealthNeurosyphilisCell activationInflammatory response