2024
Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)
Sheth S, Oh J, Bellone S, Siegel E, Greenman M, Mutlu L, McNamara B, Pathy S, Clark M, Azodi M, Altwerger G, Andikyan V, Huang G, Ratner E, Kim D, Iwasaki A, Levi A, Buza N, Hui P, Flaherty S, Schwartz P, Santin A. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147). Clinical Cancer Research 2024, 30: of1-of10. PMID: 38592381, DOI: 10.1158/1078-0432.ccr-23-3639.Peer-Reviewed Original ResearchConceptsRandomized phase II trialCD4/CD8 T cellsT cellsHPV clearanceArm BNo significant differenceClinical surveillanceRate of HPV clearanceSecondary outcomesPre-neoplastic cervical lesionsCervical intraepithelial neoplasiaT cell infiltrationT cell responsesSignificant differenceCIN3 patientsIntraepithelial neoplasiaArm ACervical lesionsImiquimod groupSurveillance armVaginal suppositoriesProspective trialsArm CHPV vaccinationImiquimod
2023
Disparities in adherence to retesting guidelines in women with Trichomonas vaginalis infection
Getaneh F, Oliveira C, Pathy S, Sheth S. Disparities in adherence to retesting guidelines in women with Trichomonas vaginalis infection. American Journal Of Obstetrics And Gynecology 2023, 229: 284.e1-284.e10. PMID: 37393012, PMCID: PMC10530237, DOI: 10.1016/j.ajog.2023.06.045.Peer-Reviewed Original ResearchConceptsHospital-based obstetricsNon-Hispanic black womenTrichomonas vaginalis infectionPregnant subgroupsClinic populationSubgroup analysisVaginalis infectionNon-Hispanic white womenGuideline-concordant testingRetrospective cohort studyTrichomonas vaginalisMultivariable logistic regressionSingle marital statusHigh prevalence ratesNon-Hispanic blacksCharacteristics of womenBlack womenHigh rateCohort studyGynecology clinicTobacco smokingGuideline recommendationsEntire cohortAssociated FactorsPrevalence rates
2018
Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic
Deshmukh U, Oliveira CR, Griggs S, Coleman E, Avni-Singer L, Pathy S, Shapiro ED, Sheth SS. Impact of a clinical interventions bundle on uptake of HPV vaccine at an OB/GYN clinic. Vaccine 2018, 36: 3599-3605. PMID: 29759380, PMCID: PMC6314176, DOI: 10.1016/j.vaccine.2018.05.039.Peer-Reviewed Original ResearchConceptsIntervention bundleOB/GYN clinicPrevalence of womenUninsured womenVaccine uptakeAttributable reductionsMissed opportunityHPV vaccine seriesVaccine-eligible visitsVaccine-eligible womenHPV vaccine uptakeMonthly rateYoung adult womenLast study monthInterrupted time series modelHPV vaccineVaccine seriesMedical recordsHispanic womenAdult womenWhite womenStudy periodYoung adultsVaccineWomen
2017
When Things Go Wrong: Examining the Frequency and Aftermath of Critical Incidents Among OBGYN Residents.
Cutler A, Black JD, Sheth SS, Pathy S. When Things Go Wrong: Examining the Frequency and Aftermath of Critical Incidents Among OBGYN Residents. Connecticut Medicine 2017, 81: 261-266. PMID: 29738126.Peer-Reviewed Original Research