2024
Age-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. PMID: 39021704, PMCID: PMC11252031, DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theory
2022
Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls
Chaudhary S, Zhornitsky S, Chao H, van Dyck C, Li C. Hypothalamic Functional Connectivity and Apathy in People with Alzheimer’s Disease and Cognitively Normal Healthy Controls. Journal Of Alzheimer's Disease 2022, 90: 1615-1628. PMID: 36314209, PMCID: PMC10064487, DOI: 10.3233/jad-220708.Peer-Reviewed Original ResearchConceptsMiddle temporal gyrusMild cognitive impairmentMotivation circuitsFunctional connectivityPath analysisWhole-brain regressionPCu/PCCState functional connectivityTotal scoreTemporal gyrusNeural markersCingulate cortexMemory dysfunctionRSFCHealthy controlsCognitive statusCognitive impairmentAlzheimer's diseaseApathyPrecuneusMemoryRsFCsDepressionScale total scoreCognitive subscoresEmotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology
Chaudhary S, Zhornitsky S, Chao HH, van Dyck CH, Li CR. Emotion Processing Dysfunction in Alzheimer’s Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology. American Journal Of Alzheimer's Disease & Other Dementias® 2022, 37: 15333175221082834. PMID: 35357236, PMCID: PMC9212074, DOI: 10.1177/15333175221082834.Peer-Reviewed Original ResearchConceptsEmotional processing deficitsProcessing dysfunctionProcessing deficitsMultiple behavioral paradigmsEmotional memoryEmotional stimuliPositive emotionsAltered emotionsNegative emotionsNeural correlatesEmotional processing dysfunctionAmygdala reactivityBehavioral findingsEmotional disordersCognitive deficitsBehavioral paradigmsProminent deficitsEmotionsAlzheimer's diseaseBehavioral studiesLongitudinal studyNoradrenergic signalingDeficitsCircuit dysfunctionMemory
2020
Domain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment
Chaudhary S, Kumaran S, Kaloiya G, Goyal V, Sagar R, Kalaivani M, Jaganathan N, Mehta N, Srivastava A. Domain specific cognitive impairment in Parkinson’s patients with mild cognitive impairment. Journal Of Clinical Neuroscience 2020, 75: 99-105. PMID: 32192853, DOI: 10.1016/j.jocn.2020.03.015.Peer-Reviewed Original ResearchConceptsMild cognitive impairmentCognitive impairmentVisuospatial functionCognitive domain specificitySpecific cognitive impairmentsCognitive Assessment testMontreal Cognitive Assessment (MoCA) testStage of MCIExecutive functionPD clinical scoresDigit spanPD-MCIPD cognitionFronto-striatalRecall domainsDomain specificityCognitive AssessmentPD groupPotential confoundsCognitionCognitive pathophysiologyCortical syndromesCategorization of subjectsMemoryNormal cognition