2023
Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia
Wong H, Wong P, Bador M, Chong M, Shenoi S, Rozanova J, Omar S, Neelamegam M, Lee Y, Rajasuriar R. Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 64-72. PMID: 36716735, DOI: 10.1097/qai.0000000000003169.Peer-Reviewed Original ResearchConceptsNew HIV diagnosesHIV diagnosisOlder adultsLate presentationYoung adultsRetrospective analysisJoin-point regression analysisAntiretroviral therapy initiationKaplan-Meier analysisNew HIV infectionsLog-rank testMalaya Medical CentreAnnual percent increaseMann-Whitney U testYoung key populationsResource-limited settingsAntiretroviral therapyTherapy initiationHIV infectionHIV testingHIV transmissionHeterosexual contactPoint regression analysisMedical CenterImmunological responseCommunity health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa
Norton S, Moll A, Madi J, Nkomo N, Brooks R, Andrews L, Shenoi S. Community health workers can be trained to identify patients eligible for tuberculosis preventive therapy, but encounter barriers to programme implementation in KwaZulu-Natal, South Africa. African Journal Of AIDS Research 2023, 22: 131-135. PMID: 37337826, DOI: 10.2989/16085906.2023.2213213.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyCommunity health workersLargest HIV epidemicCause of deathNon-communicable diseasesHealth workersPreventive therapyRural resource-limited settingsHigh TB incidence ratesFurther implementation researchTB incidence rateRate of referralResource-limited settingsMedian ageTreatment initiationHIV epidemicIncidence rateRural South AfricaHIVInfectious diseasesTuberculosisImplementation researchScreening resultsDiseasePatients
2021
Expansion of a national differentiated service delivery model to support people living with HIV and other chronic conditions in South Africa: a descriptive analysis
Liu L, Christie S, Munsamy M, Roberts P, Pillay M, Shenoi SV, Desai MM, Linnander EL. Expansion of a national differentiated service delivery model to support people living with HIV and other chronic conditions in South Africa: a descriptive analysis. BMC Health Services Research 2021, 21: 463. PMID: 34001123, PMCID: PMC8127180, DOI: 10.1186/s12913-021-06450-z.Peer-Reviewed Original ResearchConceptsNon-communicable diseasesDifferentiated service delivery modelsChronic conditionsChronic diseasesCentral Chronic Medicine DispensingLargest antiretroviral therapy (ART) programmeService delivery modelsManagement of HIVType of medicationAntiretroviral therapy programsHIV service deliveryChronic disease conditionsResource-limited settingsMedicine DispensingMixed-methods evaluationDelivery modelHealth districtHealth facilitiesNoncommunicable diseasesHIVPatientsPatient volumeTherapy programMedicationsDisease
2020
771. Prospective validation of the universal vital assessment (UVA) score to predict the in-hospital mortality of patients with acute illness admitted to a government district hospital in KwaZulu-Natal, South Africa
Ahmed A, Ladines-Lim J, Moore C, Malinga S, Moll A, Eksteen F, Shenoi S. 771. Prospective validation of the universal vital assessment (UVA) score to predict the in-hospital mortality of patients with acute illness admitted to a government district hospital in KwaZulu-Natal, South Africa. Open Forum Infectious Diseases 2020, 7: s430-s430. PMCID: PMC7776477, DOI: 10.1093/ofid/ofaa439.961.Peer-Reviewed Original ResearchUVA scoreReceiver operator characteristicDistrict hospitalSequential Organ Failure AssessmentGlasgow Coma Scale scoreOrgan Failure AssessmentHours of admissionRespiratory tract infectionsSixty one patientsSystolic blood pressureHIV-prevalent settingsHigh-risk scoreNon-communicable diseasesGovernment district hospitalsVital assessmentResource-limited settingsLogistic regression modelsBinary logistic regression modelHospital mortalityQSOFA scoreAdmission diagnosisAcute illnessCritical illnessPulmonary tuberculosisTract infections764. Correlates of Lost to Follow-up Among Newly Diagnosed Older People with HIV in Ukraine
Allen A, Zeziulin O, Postnov O, Rozanova J, Litz T, Zaviryukha I, Kiriazova T, Shenoi S. 764. Correlates of Lost to Follow-up Among Newly Diagnosed Older People with HIV in Ukraine. Open Forum Infectious Diseases 2020, 7: s427-s428. PMCID: PMC7777685, DOI: 10.1093/ofid/ofaa439.954.Peer-Reviewed Original ResearchHIV clinicSecond largest HIV epidemicMethods Retrospective chart reviewOlder peopleRetrospective chart reviewTime of diagnosisAdjusted odds ratioLargest HIV epidemicMultivariate logistic regressionHIV service deliveryResource-limited settingsCorrelates of lossHIV careART prescriptionChart reviewClinical characteristicsYounger patientsHIV outcomesMedian agePoor outcomeHIV epidemicOdds ratioFirst appointmentLTFUHIV1644. “And the stick to fight TB is IPT”: Perspectives on TPT Implementation Among Senior Nurses in Rural South Africa
Grammatico M, Ahmed A, Grau L, Moll A, Shenoi S. 1644. “And the stick to fight TB is IPT”: Perspectives on TPT Implementation Among Senior Nurses in Rural South Africa. Open Forum Infectious Diseases 2020, 7: s811-s811. PMCID: PMC7777536, DOI: 10.1093/ofid/ofaa439.1824.Peer-Reviewed Original ResearchIsoniazid preventive therapyWorld Health OrganizationPreventative therapyMedian age 39 yearsSenior nursesTB preventative therapyPatient-level factorsPrimary health clinicsPrimary care clinicsAge 39 yearsHigh-volume clinicsHealth care experiencesResource-limited settingsBackground TuberculosisAntiretroviral therapyHigh tuberculosisChronic medicationsPill burdenPreventive therapyTB burdenHigh HIVCare clinicsConclusion NursesHIV prevalenceStandardized training program
2017
“It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa
Jacobson KB, Niccolai L, Mtungwa N, Moll AP, Shenoi SV. “It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa. AIDS Care 2017, 29: 936-942. PMID: 28147705, PMCID: PMC5545149, DOI: 10.1080/09540121.2017.1283390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory Care FacilitiesAntitubercular AgentsCounselingFemaleHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHIV InfectionsHumansIncidenceInterviews as TopicIsoniazidMalePatient ComplianceQualitative ResearchRural PopulationSocial StigmaSouth AfricaTrustTuberculosisConceptsIsoniazid preventive therapyIPT completionPreventive roleAbsence of symptomsHealth care workersKnowledge of TBHealth service deliveryResource-limited settingsHealth care systemRural KwaZulu-NatalAntiretroviral therapyHIV patientsHIV diagnosisPreventive therapyTherapy completionTB incidenceAppropriate counselingHealthcare workersIndividual patientsCare workersRural South AfricaHIVPatientsUnrelated conditionsIndividual semi-structured interviews
2016
Impact of nurse-delivered community-based CD4 services on facilitating pre-ART care in rural South Africa
Kompala T, Moll AP, Mtungwa N, Brooks RP, Friedland GH, Shenoi SV. Impact of nurse-delivered community-based CD4 services on facilitating pre-ART care in rural South Africa. BMC Health Services Research 2016, 16: 374. PMID: 27515233, PMCID: PMC4982129, DOI: 10.1186/s12913-016-1627-8.Peer-Reviewed Original ResearchConceptsPre-ART careAntiretroviral treatmentCD4 testingCBVCT servicesTreatment cascadeRural South AfricaLocal primary care clinicsCD4 count resultsCommunity-based voluntary counselingPrimary care clinicsHIV-positive clientsPhlebotomy servicesResource-limited settingsART initiationHIV careART eligibilityCare cascadeCare clinicsHIV-positiveVoluntary counselingTreatment eligibilityCD4 resultsResult notificationResultsBetween 2010Nurse presence
2015
What motivates use of community-based human immunodeficiency virus testing in rural South Africa?
Upadhya D, Moll AP, Brooks RP, Friedland G, Shenoi SV. What motivates use of community-based human immunodeficiency virus testing in rural South Africa? International Journal Of STD & AIDS 2015, 27: 662-671. PMID: 26134323, PMCID: PMC4851612, DOI: 10.1177/0956462415592789.Peer-Reviewed Original ResearchConceptsHIV testingRural South AfricaRural resource-limited settingsHuman immunodeficiency virus (HIV) testingCommunity-based HIVCommunity-based testingMedian CD4 countRecent HIV exposureCommunity-based HIV testing programmeFirst-time testersHIV testing programsVoluntary HIV testingResource-limited settingsCD4 countHIV exposureMedian ageHIV statusVirus testingCommunity testingHIVCells/Rural settingsFamily membersSix-itemRisky lifestyles
2013
‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis
Shenoi SV, Brooks RP, Catterick K, Moll AP, Friedland GH. ‘Cough officer’ nurses in a general medical clinic successfully detect drug-susceptible and -resistant tuberculosis. Public Health Action 2013, 3: 46-50. PMID: 25392815, PMCID: PMC4226409, DOI: 10.5588/pha.12.0056.Peer-Reviewed Original ResearchGeneral medical clinicDrug-resistant tuberculosisMedical clinicsClinic attendeesTB suspectsHuman immunodeficiency virus (HIV) patientsHigh HIV prevalence settingsZiehl-NeelsenProportion of patientsHIV prevalence settingsCulture-positive casesResource-limited settingsWorld Health OrganizationTB screeningVirus patientsHigh HIVResistant tuberculosisPatient populationTB prevalencePrevalence settingsReferral laboratoryTuberculosisDrug resistancePatientsClinic
2010
Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts
Shenoi SV, Escombe AR, Friedland G. Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts. Clinical Infectious Diseases 2010, 50: s231-s237. PMID: 20397953, PMCID: PMC3029014, DOI: 10.1086/651496.Peer-Reviewed Original ResearchConceptsInfection control strategiesResource-limited settingsHIV infectionInfection controlActive antiretroviral therapy rolloutHuman immunodeficiency virus (HIV) infectionAntiretroviral therapy rolloutTransmission of drugDrug-resistant TBImmunodeficiency virus infectionDrug-resistant tuberculosisHealth care workersAirborne infection controlNosocomial transmissionTuberculosis careVirus infectionCare workersInfectionCurrent outbreakHigh rateTBPotential benefitsMorbidityHIVTuberculosis