2024
Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study
Su J, Yeo Y, Jeetoo M, Morojele N, Francis J, Shenoi S, Braithwaite R. Cost-effectiveness of screening and treating alcohol use and depression among people living with HIV in Zimbabwe: a mathematical modeling study. BMC Medicine 2024, 22: 481. PMID: 39428460, PMCID: PMC11492560, DOI: 10.1186/s12916-024-03674-8.Peer-Reviewed Original ResearchConceptsCognitive-behavioral therapyBackgroundAlcohol use disorderTreating alcohol useCompared to baselineLong-acting PrEPDepressive disorderTreat AUDUse disorderMDDMDD screeningAlcohol usePHQ-9Quality-adjusted life yearsAUDCost-effectiveness of screeningSub-Saharan African settingDisordersImpact of screeningIntervention costsHIV infectionHIV transmissionHIV reductionInterventionHIV outcomesHIV epidemic
2023
Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia
Wong H, Wong P, Bador M, Chong M, Shenoi S, Rozanova J, Omar S, Neelamegam M, Lee Y, Rajasuriar R. Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 64-72. PMID: 36716735, DOI: 10.1097/qai.0000000000003169.Peer-Reviewed Original ResearchConceptsNew HIV diagnosesHIV diagnosisOlder adultsLate presentationYoung adultsRetrospective analysisJoin-point regression analysisAntiretroviral therapy initiationKaplan-Meier analysisNew HIV infectionsLog-rank testMalaya Medical CentreAnnual percent increaseMann-Whitney U testYoung key populationsResource-limited settingsAntiretroviral therapyTherapy initiationHIV infectionHIV testingHIV transmissionHeterosexual contactPoint regression analysisMedical CenterImmunological response
2019
Low expression Macrophage Migration Inhibitory Factor (MIF) alleles and tuberculosis in HIV infected South Africans
Reid D, Shenoi S, Singh R, Wang M, Patel V, Das R, Hiramen K, Moosa Y, Eksteen F, Moll AP, Ndung'u T, Kasprowicz V, Leng L, Friedland GH, Bucala R. Low expression Macrophage Migration Inhibitory Factor (MIF) alleles and tuberculosis in HIV infected South Africans. Cytokine X 2019, 1: 100004. PMID: 33604547, PMCID: PMC7885893, DOI: 10.1016/j.cytox.2019.100004.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorHigh prevalenceCytokine macrophage migration inhibitory factorLow expressionLaboratory-confirmed tuberculosisLow CD4 cellsTB disease casesHIV-positive cohortMigration inhibitory factorPromoter variantsHIV immunosuppressionMIF levelsActive tuberculosisCD4 cellsHIV infectionTB statusClinical informationHost immunityHIVDisease casesInhibitory factorTuberculosisFunctional polymorphismsC SNPGreater frequency
2018
Synergism between diabetes and human immunodeficiency virus in increasing the risk of tuberculosis
Sinha P, Moll AP, Brooks RP, Deng YH, Shenoi SV. Synergism between diabetes and human immunodeficiency virus in increasing the risk of tuberculosis. The International Journal Of Tuberculosis And Lung Disease 2018, 22: 793-799. PMID: 29914606, PMCID: PMC6050202, DOI: 10.5588/ijtld.17.0936.Peer-Reviewed Original ResearchConceptsRisk of tuberculosisDiabetes mellitusTB symptomsOdds ratioHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionHuman immunodeficiency virusCommunity health screeningCross-sectional studyCommunity health projectsActive tuberculosisHIV infectionHIV positivityPrimary outcomeImmunodeficiency virusScreening servicesHealth screeningCongregate settingsVirus infectionResource-limited regionsMultiplicative scaleHIVMultivariate analysisRetrospective dataTuberculosis
2014
Disseminated tuberculosis manifesting as cholestasis in a patient with AIDS: a presentation to remember
Lee TM, Shenoi SV, Ogbuagu O. Disseminated tuberculosis manifesting as cholestasis in a patient with AIDS: a presentation to remember. BMJ Case Reports 2014, 2014: bcr2013201824. PMID: 24567181, PMCID: PMC3939406, DOI: 10.1136/bcr-2013-201824.Peer-Reviewed Case Reports and Technical NotesConceptsDisseminated tuberculosisCT scanChronic untreated HIV infectionSubsequent CT scanUntreated HIV infectionGeneXpert PCRMiliary infiltratesUnremarkable workupInduced sputumPersistent feverCholestatic jaundiceHIV infectionInfectious etiologyLiver diseasePleural effusionUnusual presentationTuberculosisCholestasisMycobacterium tuberculosisWeight lossJaundicePatientsIndian descentAIDSPresentation
2010
Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts
Shenoi SV, Escombe AR, Friedland G. Transmission of Drug-Susceptible and Drug-Resistant Tuberculosis and the Critical Importance of Airborne Infection Control in the Era of HIV Infection and Highly Active Antiretroviral Therapy Rollouts. Clinical Infectious Diseases 2010, 50: s231-s237. PMID: 20397953, PMCID: PMC3029014, DOI: 10.1086/651496.Peer-Reviewed Original ResearchConceptsInfection control strategiesResource-limited settingsHIV infectionInfection controlActive antiretroviral therapy rolloutHuman immunodeficiency virus (HIV) infectionAntiretroviral therapy rolloutTransmission of drugDrug-resistant TBImmunodeficiency virus infectionDrug-resistant tuberculosisHealth care workersAirborne infection controlNosocomial transmissionTuberculosis careVirus infectionCare workersInfectionCurrent outbreakHigh rateTBPotential benefitsMorbidityHIVTuberculosis