2008
Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea.
Akhtar S, Podgoreanu M, Harrison B, Brull S. Effect of lidocaine on endothelin-1-mediated airway smooth muscle contraction in the rat trachea. Minerva Anestesiologica 2008, 74: 643-50. PMID: 18971893.Peer-Reviewed Original ResearchConceptsEffects of lidocaineEndothelin-1Extracellular calciumRat tracheaAirway smooth muscle constrictionET-1-induced constrictionET-1-induced contractionAirway smooth muscle contractionCarbachol concentration-response curveDirect relaxant effectIntracellular calcium entryET-1 responseSmooth muscle constrictionNM ET-1Concentration-response curvesG-protein-coupled endothelin receptorsSmooth muscle contractionUnpaired t-testASM contractionContractile responseMaximal contractilityRelaxant effectASM relaxationEndothelin receptorsMuscle constrictionPreoperative β-blocker use: impact of national guidelines on clinical practice
Akhtar S, Assaad, Amin M, Holt NF, Barash PG, Silverman DG. Preoperative β-blocker use: impact of national guidelines on clinical practice. Journal Of Clinical Anesthesia 2008, 20: 122-128. PMID: 18410867, DOI: 10.1016/j.jclinane.2007.09.012.Peer-Reviewed Original ResearchConceptsBeta-blocker groupPost-guideline patientsPre-guideline groupVascular surgery patientsCoronary artery bypassTarget HRArtery bypassSurgery patientsPerioperative beta-blocker therapyPreoperative beta-blocker useTertiary care teaching hospitalMean HRElective vascular surgeryPost-guideline groupVascular surgery groupBeta-blocker therapyBeta-blocker useUnpaired t-testEligible patientsSurgery groupPreanesthetic evaluationVascular surgeryPresurgical patientsTeaching hospitalObservational study
2005
Preoperative β-blocker use: is titration to a heart rate of 60 beats per minute a consistently attainable goal?
Akhtar S, Amin M, Tantawy H, Senior A, Barash PG, Silverman DG. Preoperative β-blocker use: is titration to a heart rate of 60 beats per minute a consistently attainable goal? Journal Of Clinical Anesthesia 2005, 17: 191-197. PMID: 15896586, DOI: 10.1016/j.jclinane.2004.06.020.Peer-Reviewed Original ResearchConceptsPreinduction heart ratePerioperative beta-blocker useBeta-blocker useHeart rateCABG patientsEligible patientsSurgery patientsCoronary artery bypass graft surgeryArtery bypass graft surgeryTertiary care teaching hospitalBeta-blocker intoleranceCABG surgery patientsBeta-blocker therapyBypass graft surgeryVascular surgery patientsRetrospective observational studyUnpaired t-testBlocker groupGraft surgeryNoncardiac surgeryVascular patientsVascular surgeryTeaching hospitalObservational studyCurrent recommendations