2013
Viral Infection of the Pregnant Cervix Predisposes to Ascending Bacterial Infection
Racicot K, Cardenas I, Wünsche V, Aldo P, Guller S, Means RE, Romero R, Mor G. Viral Infection of the Pregnant Cervix Predisposes to Ascending Bacterial Infection. The Journal Of Immunology 2013, 191: 934-941. PMID: 23752614, PMCID: PMC4153356, DOI: 10.4049/jimmunol.1300661.Peer-Reviewed Original ResearchConceptsFemale reproductive tractBacterial infectionsViral infectionLower female reproductive tractReproductive tractAntimicrobial peptide expressionProduction of mucusPreterm laborPreterm birthNeonatal mortalityUterine cavityUterine infectionMouse modelPeptide expressionInfectionCervixPolymicrobial diseaseMajor causeMultifactorial approachCommon routePregnancyBirthUterusTractAntimicrobial peptides
2012
Cutting‐Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan‐Induced Trophoblast Apoptosis
Mulla MJ, Myrtolli K, Tadesse S, Stanwood NL, Gariepy A, Guller S, Norwitz ER, Abrahams VM. Cutting‐Edge Report: TLR10 Plays a Role in Mediating Bacterial Peptidoglycan‐Induced Trophoblast Apoptosis. American Journal Of Reproductive Immunology 2012, 69: 449-453. PMID: 23279063, PMCID: PMC3620725, DOI: 10.1111/aji.12065.Peer-Reviewed Original ResearchConceptsIL-6 secretionTrophoblast apoptosisTLR2 coreceptorsHuman trophoblast cell lineIntrauterine bacterial infectionFirst-trimester human trophoblast cell lineThird-trimester human placental tissueHuman placental tissueTrophoblast cell linePositive bacterial componentsTLR10 expressionPreterm laborThird trimesterCaspase-3 activityIL-6TLR2 activationPlacental tissuePlacental apoptosisBacterial infectionsTLR10Bacterial componentsBacterial peptidoglycanTrophoblastCell linesApoptosis
2005
A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells
Abrahams VM, Visintin I, Aldo PB, Guller S, Romero R, Mor G. A Role for TLRs in the Regulation of Immune Cell Migration by First Trimester Trophoblast Cells. The Journal Of Immunology 2005, 175: 8096-8104. PMID: 16339547, DOI: 10.4049/jimmunol.175.12.8096.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsInnate immune cellsMaternal-fetal interfaceTrophoblast cellsIntrauterine infectionPregnancy complicationsNormal pregnancyImmune cellsImmune responseImmune systemHuman first trimester trophoblast cellsGrowth-related oncogene alphaCertain pregnancy complicationsElevated leukocyte infiltrationMaternal immune systemGrowth-related oncogeneTLR-3 stimulationImmune cell migrationSecretion of chemokinesInnate immune systemElevated monocytesPaternal AgsPreterm laborNK cellsTLR-3