2007
Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction
Bahtiyar MO, Buhimschi C, Ravishankar V, Copel J, Norwitz E, Julien S, Guller S, Buhimschi IA. Contrasting effects of chronic hypoxia and nitric oxide synthase inhibition on circulating angiogenic factors in a rat model of growth restriction. American Journal Of Obstetrics And Gynecology 2007, 196: 72.e1-72.e6. PMID: 17240241, DOI: 10.1016/j.ajog.2006.07.048.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChronic DiseaseDisease Models, AnimalEnzyme InhibitorsFemaleFetal Growth RetardationHypoxiaNG-Nitroarginine Methyl EsterNitric Oxide SynthasePlacenta Growth FactorPregnancyPregnancy ProteinsRatsRats, Sprague-DawleyVascular Endothelial Growth Factor Receptor-1Vascular Endothelial Growth FactorsConceptsVascular endothelial growth factorL-NAMESerum levelsChronic hypoxiaSoluble fms-like tyrosine kinase-1Nitro-L-arginine methyl esterFms-like tyrosine kinase-1Adult Sprague-Dawley ratsGrowth factorMaternal serum levelsFree serum levelsIntrauterine growth restrictionOnset of laborPlacental growth factorTyrosine kinase-1Subcutaneous osmotic pumpsSprague-Dawley ratsNitric oxide inhibitionEndothelial growth factorNonpregnant controlsSFlt-1Growth restrictionHypoxic chamberMaternal bloodOxide inhibition
2006
Fractional Excretion of Angiogenic Factors in Women With Severe Preeclampsia
Buhimschi CS, Magloire L, Funai E, Norwitz ER, Kuczynski E, Martin R, Richman S, Guller S, Lockwood CJ, Buhimschi IA. Fractional Excretion of Angiogenic Factors in Women With Severe Preeclampsia. Obstetrics And Gynecology 2006, 107: 1103-1113. PMID: 16648417, DOI: 10.1097/01.aog.0000207698.74104.4f.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorPlacental growth factorEndothelial growth factorProtein/creatinine ratioTotal protein/creatinine ratioPreeclamptic womenFractional excretionSevere preeclampsiaCreatinine ratioSFlt-1Angiogenic factorsGrowth factorPregnant controlsSoluble fms-like tyrosine kinase-1Serum placental growth factor levelsUrinary vascular endothelial growth factorFms-like tyrosine kinase-1Placental growth factor levelsHealthy pregnant controlsHealthy pregnant womenDisease clinical manifestationsGrowth factor levelsTyrosine kinase-1Preeclamptic groupRenal production
2005
Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
Buhimschi CS, Norwitz ER, Funai E, Richman S, Guller S, Lockwood CJ, Buhimschi IA. Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia. American Journal Of Obstetrics And Gynecology 2005, 192: 734-741. PMID: 15746665, DOI: 10.1016/j.ajog.2004.12.052.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorSevere preeclampsiaHypertensive disordersHypertensive womenUrinary levelsUrinary outputSFlt-1Soluble fms-like tyrosine kinase-1Fms-like tyrosine kinase-1Antiangiogenic factors sFlt-1Growth factorSFlt-1 concentrationsHealthy pregnant controlsPlacental growth factorTime of enrollmentTyrosine kinase-1Urinary protein measurementsEndothelial growth factorClinical preeclampsiaProteinuric womenPlGF levelsNonpregnant womenPlGF ratioPregnant controlsGestational age
2002
Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β
Ma Y, Ryu JS, Dulay A, Segal M, Guller S. Regulation of Plasminogen Activator Inhibitor (PAI)-1 Expression in a Human Trophoblast Cell Line by Glucocorticoid (GC) and Transforming Growth Factor (TGF)-β. Placenta 2002, 23: 727-734. PMID: 12398812, DOI: 10.1053/plac.2002.0863.Peer-Reviewed Original ResearchConceptsHTR-8/SVneo cellsIntrauterine growth restrictionPAI-2 levelsPAI-1 expressionPlasminogen activator inhibitorActivator inhibitorGrowth factorHuman trophoblast cell linePAI-1 levelsTrophoblast cell lineTransforming Growth FactorTGF-beta treatmentTGF-beta effectsPAI-1 proteinFibrin depositionGrowth restrictionDEX treatmentSynthetic glucocorticoidGlucocorticoidsPAI-1Regulation of fibrinolysisDexamethasoneTGF betaExcessive productionMRNA expression