2008
The Placental Syncytium and the Pathophysiology of Preeclampsia and Intrauterine Growth Restriction
Guller S, Y. Y, Fu H, Krikun G, Abrahams VM, Mor G. The Placental Syncytium and the Pathophysiology of Preeclampsia and Intrauterine Growth Restriction. Annals Of The New York Academy Of Sciences 2008, 1127: 129-133. PMID: 18443340, PMCID: PMC3671376, DOI: 10.1196/annals.1434.015.Peer-Reviewed Original ResearchConceptsIntrauterine growth restrictionPathophysiology of preeclampsiaGrowth restrictionPlacental syncytiumFms-like tyrosine kinase-1Complications of pregnancyPlasminogen activator inhibitor-1Tyrosine kinase-1Activator inhibitor-1Release of factorsPlacental damageSoluble endoglinEndothelium dysfunctionLaser capture microdissectionMaternal bloodAntiangiogenic factorsPreeclampsiaFas ligandWestern blottingInhibitor-1Reactive oxygen speciesCapture microdissectionPregnancyPathophysiologyKinase 1
2004
A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response
Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E, Rahman M, Caze R, Qumsiyeh M, Lockwood CJ. A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response. Endocrinology 2004, 145: 2291-2296. PMID: 14726435, DOI: 10.1210/en.2003-1606.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TransformedDeciduaEndometriumEstradiolFas Ligand ProteinFas ReceptorFemaleFibronectinsGene ExpressionHot TemperatureHumansInsulin-Like Growth Factor Binding Protein 1KaryotypingMedroxyprogesterone AcetateMembrane GlycoproteinsPlasminogen Activator Inhibitor 1ProgestinsProlactinStromal CellsTelomeraseThromboplastinConceptsHuman endometrial stromal cellsImmortalized human endometrial stromal cell lineHuman endometrial stromal cell lineCultured human endometrial stromal cellsEndometrial stromal cell linePrimary human endometrial stromal cellsPlasminogen activator inhibitor-1Endometrial stromal cellsExpression of IGFFas/Fas ligandActivator inhibitor-1Cell linesProgestational responseParent cellsOvarian steroidsMedroxyprogesterone acetateDecidualization responseAbnormal karyotypeStromal cell lineTissue factorNew cell lineStromal cellsFas ligandInhibitor-1Process of immortalizationFirst trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis
Abrahams VM, Straszewski-Chavez S, Guller S, Mor G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Molecular Human Reproduction 2004, 10: 55-63. PMID: 14665707, DOI: 10.1093/molehr/gah006.Peer-Reviewed Original ResearchConceptsFirst trimester trophoblast cellsImmune privilegeTrophoblast cellsFas/Fas ligand (FasL) apoptotic pathwayMaternal immune recognitionMaternal immune systemImmune cell apoptosisSecretion of FasLT cell deathPaternal alloantigensAllograft rejectionNormal pregnancyPeripheral toleranceImmune recognitionImmune systemRelease of microvesiclesFas ligandCell apoptosisVivo studiesFasLMembrane-associated expressionTrophoblastIntracellular FasLApoptotic pathwayDeath