2013
Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection
Price RW, Peterson J, Fuchs D, Angel TE, Zetterberg H, Hagberg L, Spudich S, Smith RD, Jacobs JM, Brown JN, Gisslen M. Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection. Journal Of Neuroimmune Pharmacology 2013, 8: 1147-1158. PMID: 23943280, PMCID: PMC3889225, DOI: 10.1007/s11481-013-9491-3.Peer-Reviewed Original ResearchConceptsHIV infectionCentral nervous system infectionSystemic HIV infectionNervous system infectionCNS disease progressionCerebrospinal fluid biomarkersCross-sectional studyInteraction of HIVCSF biomarker studiesCNS infectionsDisease activitySystem infectionAntiretroviral treatmentClinical stagingNeural injuryCSF biomarkersNeurological consequencesFluid biomarkersDisease progressionMore accurate diagnosisNeuropsychological test performanceNovel biomarkersAccurate diagnosisBiomarker concentrationsInfection
2012
The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
Angel TE, Jacobs JM, Spudich SS, Gritsenko MA, Fuchs D, Liegler T, Zetterberg H, Camp DG, Price RW, Smith RD. The cerebrospinal fluid proteome in HIV infection: change associated with disease severity. Clinical Proteomics 2012, 9: 3. PMID: 22433316, PMCID: PMC3353874, DOI: 10.1186/1559-0275-9-3.Peer-Reviewed Original ResearchCNS HIV infectionHIV infectionCerebrospinal fluidChronic asymptomatic infectionSystemic HIV infectionNervous system infectionAmyloid precursor proteinCSF proteomic analysisCerebrospinal fluid proteomeCSF neopterinAntiretroviral therapyDifferent time pointsSystem infectionNeural injuryImmune activationMotor dysfunctionAsymptomatic infectionClinical spectrumCSF biomarkersCSF analysisDisease progressionCSF samplesNeuronal plasticityDisease severityInfection
2009
Amyloid and tau cerebrospinal fluid biomarkers in HIV infection
Gisslén M, Krut J, Andreasson U, Blennow K, Cinque P, Brew BJ, Spudich S, Hagberg L, Rosengren L, Price RW, Zetterberg H. Amyloid and tau cerebrospinal fluid biomarkers in HIV infection. BMC Neurology 2009, 9: 63. PMID: 20028512, PMCID: PMC2807422, DOI: 10.1186/1471-2377-9-63.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAIDS Dementia ComplexAIDS-Related Opportunistic InfectionsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnalysis of VarianceBiomarkersCross-Sectional StudiesFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedPeptide FragmentsPrincipal Component AnalysisTau ProteinsConceptsAIDS dementia complexCerebrospinal fluid biomarkersOpportunistic infectionsADC patientsAlzheimer's diseaseHIV infectionP-tauDisease patientsFluid biomarkersCentral nervous system opportunistic infectionsSoluble amyloid precursor protein alphaLower CSF Aβ1-42CSF t-tau levelsCNS immune activationCNS opportunistic infectionsCSF p-tauCSF t-tauT-tau levelsCross-sectional studyCSF Aβ1-42Alzheimer's disease patientsUninfected subjectsInfection patientsNeural injuryNeurological symptoms