2016
Putamen volume and its clinical and neurological correlates in primary HIV infection
Wright PW, Pyakurel A, Vaida FF, Price RW, Lee E, Peterson J, Fuchs D, Zetterberg H, Robertson KR, Walter R, Meyerhoff DJ, Spudich SS, Ances BM. Putamen volume and its clinical and neurological correlates in primary HIV infection. AIDS 2016, 30: 1789-1794. PMID: 27045376, PMCID: PMC4925211, DOI: 10.1097/qad.0000000000001103.Peer-Reviewed Original ResearchConceptsEarly HIV infectionHIV infectionPutamen volumeCerebrospinal fluidCD4/CD8 ratioCentral nervous system changesCross-sectional neuroimaging studiesTrajectory of HIVCD4 cell countPrimary HIV infectionCortical white matterTotal gray matterNervous system changesEarly HIVFreeSurfer 5.1CD8 ratioT1 MRI scansNeuropsychometric testsNatural coursePHI groupCorpus callosumInterventional strategiesInfection durationNeuropsychological testingVolumetric alterations
2014
Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection
Suh J, Sinclair E, Peterson J, Lee E, Kyriakides TC, Li FY, Hagberg L, Fuchs D, Price RW, Gisslen M, Spudich S. Progressive increase in central nervous system immune activation in untreated primary HIV-1 infection. Journal Of Neuroinflammation 2014, 11: 199. PMID: 25465205, PMCID: PMC4263211, DOI: 10.1186/s12974-014-0199-y.Peer-Reviewed Original ResearchConceptsPrimary HIV-1 infectionHIV-1 infectionCSF neopterinCerebrospinal fluidT cellsHIV infectionCentral nervous system immune activationUntreated primary HIV-1 infectionBaseline levelsEarly HIV-1 infectionCSF neopterin concentrationsNervous system inflammationMixed effects modelsCluster of differentiationMajority of subjectsCNS inflammationSystem inflammationAverage followNeopterin concentrationsHIV transmissionImmune activationLumbar punctureResultsA totalIntrathecal inflammationNatural course