2024
Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV
Patel P, Prince D, Bolenzius J, Ch’en P, Chiarella J, Kolind S, Vavasour I, Pedersen T, Levendovszky S, Spudich S, Marra C, Paul R. Medical comorbidities and lower myelin content are associated with poor cognition in young adults with perinatally acquired HIV. AIDS 2024, 38: 1932-1939. PMID: 39110577, PMCID: PMC11524773, DOI: 10.1097/qad.0000000000003989.Peer-Reviewed Original ResearchPoor cognitionCognitive impairmentHorizontally acquired HIVMarkers of cognitive reserveAssociated with poorer cognitionRisk factorsCross-sectional studyYoung adultsLower cognitive scoresYears of educationMultiple cognitive domainsExperience cognitive deficitsCognitive domain scoresHIV-uninfected controlsOlder adultsCorticospinal tractCognitive batteryDomain scoresMedical comorbidityCognitive deficitsCognitive domainsMyelin contentCognitive reserveNeuroimaging dataCognitive scores
2022
Decreased Myelin Content and Associated Cognitive Performance in Adults Living with Perinatally-Acquired HIV (S38.003)
Patel P, Vecchio A, Ch’en P, Chiarella J, Kolind S, Hoff M, Spudich S, Marra C, Paul R, Levendovszky S. Decreased Myelin Content and Associated Cognitive Performance in Adults Living with Perinatally-Acquired HIV (S38.003). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.1398.Peer-Reviewed Original ResearchDecreased Myelin Content on Myelin Water Imaging and Correlation with Cognitive Performance in Adults with Perinatal HIV
Patel P, Vecchio A, Chen P, Chiarella J, Kolind S, Hoff M, Dvorak A, Vavasour I, Spudich S, Marra C, Paul R, Rane S. Decreased Myelin Content on Myelin Water Imaging and Correlation with Cognitive Performance in Adults with Perinatal HIV. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2022 DOI: 10.58530/2022/3970.Peer-Reviewed Original ResearchCognitive impairmentCerebral white matter injuryMyelin water fractionWhite matter injuryMyelin contentCohort of adultsPerinatal HIVPathologic substrateMyelin water imagingHIVPHIVAdultsCognitive performanceExecutive functionImpairmentWater imagingCognitive profileInjuryCohortMyelin waterMyelinationPathology