2016
CROI 2016: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2016: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2016, 24: 29-37. PMID: 27398860, PMCID: PMC6148921.Peer-Reviewed Original ResearchConceptsCentral nervous systemHIV infectionTraditional vascular risk factorsPrognosis of handSuppressive antiretroviral treatmentVascular risk factorsStandard antiretroviral therapyPotential adjunctive therapyLarge epidemiologic studiesMacrophage lineage cellsRecreational drug useHIV escapeHIV measuresAntiretroviral therapyHepatic dysfunctionNeurologic complicationsAdjunctive therapyAntiretroviral treatmentSystemic compartmentOpportunistic infectionsHIV replicationFemale sexPotential complicationsRisk factorsNeurocognitive disorders
2012
Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load
Peluso MJ, Ferretti F, Peterson J, Lee E, Fuchs D, Boschini A, Gisslén M, Angoff N, Price RW, Cinque P, Spudich S. Cerebrospinal fluid HIV escape associated with progressive neurologic dysfunction in patients on antiretroviral therapy with well controlled plasma viral load. AIDS 2012, 26: 1765-1774. PMID: 22614889, PMCID: PMC3881435, DOI: 10.1097/qad.0b013e328355e6b2.Peer-Reviewed Original ResearchConceptsCSF HIV RNAAntiretroviral therapyHIV RNACopies/CSF escapeNeurologic abnormalitiesCerebrospinal fluidMedian CD4 T-cell countDetectable CSF HIV RNAMedian plasma HIV RNACD4 T-cell countCentral nervous system exposureNew neurologic abnormalitiesPlasma HIV levelsPlasma HIV RNAProgressive neurologic abnormalitiesStable ART regimenPlasma viral loadT-cell countsElevated CSF proteinRetrospective case seriesProgressive neurologic dysfunctionUrban medical centerCSF RNAHIV escape