2015
Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV
Valcour VG, Spudich SS, Sailasuta N, Phanuphak N, Lerdlum S, Fletcher JL, Kroon ED, Jagodzinski LL, Allen IE, Adams CL, Prueksakaew P, Slike BM, Hellmuth JM, Kim JH, Ananworanich J, . Neurological Response to cART vs. cART plus Integrase Inhibitor and CCR5 Antagonist Initiated during Acute HIV. PLOS ONE 2015, 10: e0142600. PMID: 26555069, PMCID: PMC4640512, DOI: 10.1371/journal.pone.0142600.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyStandard combination antiretroviral therapyLog10 HIV RNAAcute HIVCSF cytokinesHIV RNACentral nervous system outcomesIntegrase inhibitorsGamma-induced protein 10Duration of HIVFiebig stages IAcute HIV infectionHIV RNA levelsCNS outcomesAntiretroviral therapyInflammatory markersWeek 24Antiretroviral treatmentHIV infectionPlasma neopterinRandomized armProspective evaluationMean ageHealthy controlsCCR5 antagonists
2013
Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection
Peluso MJ, Meyerhoff DJ, Price RW, Peterson J, Lee E, Young AC, Walter R, Fuchs D, Brew BJ, Cinque P, Robertson K, Hagberg L, Zetterberg H, Gisslén M, Spudich S. Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection. The Journal Of Infectious Diseases 2013, 207: 1703-1712. PMID: 23460748, PMCID: PMC3636785, DOI: 10.1093/infdis/jit088.Peer-Reviewed Original ResearchConceptsPrimary HIV infectionNeurofilament light chainHIV infectionAmyloid precursor proteinCerebrospinal fluidNeuronal injuryT-tauCSF/plasma albumin ratioPrimary human immunodeficiency virus (HIV) infectionCentral nervous system inflammationHuman immunodeficiency virus (HIV) infectionSoluble amyloid precursor proteinGamma-induced protein 10Primary infection groupNervous system inflammationImmunodeficiency virus infectionEarly neuronal injuryPlasma albumin ratioParietal gray matterGlutamate/creatineLight chainPrecursor proteinProton magnetic resonance spectroscopyFrontal white matterWhite blood cells