2018
CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection
Gisslén M, Heslegrave A, Veleva E, Yilmaz A, Andersson LM, Hagberg L, Spudich S, Fuchs D, Price RW, Zetterberg H. CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection. Neurology Neuroimmunology & Neuroinflammation 2018, 6: e512. PMID: 30568991, PMCID: PMC6278890, DOI: 10.1212/nxi.0000000000000512.Peer-Reviewed Original ResearchConceptsHIV-1 infectionHIV-negative controlsMicroglial activationNeuronal injuryCSF concentrationsUntreated HIV-1-infected patientsHIV-1 disease severityHIV-1-infected adultsMacrophage/microglial activationHIV-1-infected patientsRetrospective cross-sectional studyUntreated HIV-1 infectionCNS immune activationCSF sTREM2 levelsSuppressive antiretroviral treatmentT-cell countsMicroglial activation markersT cell lossLevels of CSFNeurofilament light proteinCross-sectional studyCSF sTREM2STREM2 levelsAntiretroviral treatmentActivation markers
2017
Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls
Yilmaz A, Blennow K, Hagberg L, Nilsson S, Price RW, Schouten J, Spudich S, Underwood J, Zetterberg H, Gisslén M. Neurofilament light chain protein as a marker of neuronal injury: review of its use in HIV-1 infection and reference values for HIV-negative controls. Expert Review Of Molecular Diagnostics 2017, 17: 761-770. PMID: 28598205, DOI: 10.1080/14737159.2017.1341313.Peer-Reviewed Original ResearchConceptsHIV-negative controlsCSF NFL concentrationsNeuronal injuryNeurofilament proteinNfL concentrationsNeurofilament light chain proteinHIV CNS infectionEarly acute phaseHIV-1 infectionAge-related upper limitCNS infectionsSevere immunosuppressionAntiretroviral treatmentHIV infectionNeuronal damageAcute phaseCNS injuryCSF biomarkersLumbar punctureCSF concentrationsNerve conductionNeurological conditionsSensitive markerNeurological diseasesLight chain protein
2014
Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW. Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection. PLOS ONE 2014, 9: e116081. PMID: 25541953, PMCID: PMC4277428, DOI: 10.1371/journal.pone.0116081.Peer-Reviewed Original ResearchConceptsNeurofilament light chain proteinT-tau levelsNeuronal biomarkersViral suppressionHIV infectionPrimary infectionCentral nervous system HIV infectionCSF t-tau levelsCSF Aβ peptidesHIV disease progressionAge-adjusted normsSoluble amyloid precursorHierarchy of sensitivityBlood CD4CD4 50HAD patientsHAD subjectsCD4 declineNeuronal injuryCross-sectional designProgressive injuryHIV progressionCSF biomarkersCSF concentrationsDisease progression