Featured Publications
Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation
Gu SX, Tyagi T, Jain K, Gu VW, Lee SH, Hwa JM, Kwan JM, Krause DS, Lee AI, Halene S, Martin KA, Chun HJ, Hwa J. Thrombocytopathy and endotheliopathy: crucial contributors to COVID-19 thromboinflammation. Nature Reviews Cardiology 2020, 18: 194-209. PMID: 33214651, PMCID: PMC7675396, DOI: 10.1038/s41569-020-00469-1.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdministration, InhalationAnticoagulantsBlood Coagulation DisordersBlood Platelet DisordersCOVID-19COVID-19 Drug TreatmentEndothelium, VascularEndothelium-Dependent Relaxing FactorsEpoprostenolHeart Disease Risk FactorsHumansIloprostInflammationNitric OxidePlatelet Aggregation InhibitorsSARS-CoV-2Systemic Inflammatory Response SyndromeThrombosisThrombotic MicroangiopathiesVascular DiseasesVasodilator AgentsVenous ThromboembolismConceptsCardiovascular risk factorsRisk factorsCOVID-19Severe acute respiratory syndrome coronavirus 2Pre-existing cardiovascular diseaseAcute respiratory syndrome coronavirus 2Traditional cardiovascular risk factorsAcute respiratory distress syndromeRespiratory syndrome coronavirus 2Respiratory distress syndromeManagement of patientsSyndrome coronavirus 2COVID-19 pathologyCoronavirus disease 2019Potential therapeutic strategyCytokine stormEndothelial dysfunctionThrombotic complicationsDistress syndromeExcessive inflammationCoronavirus 2Severe outcomesAdvanced ageCardiovascular diseaseDisease 2019
2023
Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders
Gu S, Gallagher P, Butt A, Gu V, Lezon-Geyda K, Schulz V, Prozora S, Lee A, Neparidze N, Bar N, Martin K, Cornell J, Chirico G, Chakraborty R, Rinder H, Hwa J, Bona R. Multimodality Platelet Evaluation By Mass Cytometry and Genetic Analysis in Patients with Bleeding Disorders. Blood 2023, 142: 1197. DOI: 10.1182/blood-2023-177946.Peer-Reviewed Original ResearchBleeding tendencyBleeding disorderPlatelet markersPlatelet aggregometryMass cytometryPlatelet functionPlatelet disordersSingle-center prospective studyLow-risk groupAbnormal bleeding tendencyQualitative platelet disordersLarge patient cohortQuantitative platelet disordersCommon underlying causeGenetic variantsMultimodality evaluationTotal patientsRisk stratificationLaboratory suspicionPlatelet dysfunctionProspective studyPatient cohortUnivariate analysisPlatelet volumeRisk groupsFishing for “complements” with vascular organoid models of microvascular disease
Gu S, Yarovinsky T, Hwa J. Fishing for “complements” with vascular organoid models of microvascular disease. Cell Stem Cell 2023, 30: 1285-1286. PMID: 37802032, DOI: 10.1016/j.stem.2023.09.004.Peer-Reviewed Original ResearchHelicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis
Gu S, Siddon A, Huntington S, Jain D. Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis. American Journal Of Clinical Pathology 2023, 160: 612-619. PMID: 37556379, PMCID: PMC10691190, DOI: 10.1093/ajcp/aqad088.Peer-Reviewed Original ResearchConceptsHP-positive patientsLymphoid tissue lymphomaChronic gastritisMALT lymphomaHP-negative casesTissue lymphomaHelicobacter pylori-negative mucosaPrimary gastric MALT lymphomaB-cell gene rearrangementsAvailable pathology reportsHP-negative patientsGastric MALT lymphomaHP-negative groupHelicobacter pylori infectionReview of slidesMALT lymphoma casesAdditional laboratory testingHP eradicationDisease recurrenceOptimal management strategyClinicopathologic analysisClinicopathologic featuresHistologic gastritisHP-positive casesInitial diagnosisInsights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter
Sharda A, Gu S, Hwa J. Insights into platelet pharmacology from a cryo-EM structure of the ABCC4 transporter. Nature Cardiovascular Research 2023, 2: 606-608. PMID: 37655224, PMCID: PMC10470688, DOI: 10.1038/s44161-023-00293-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsSOD2 in platelets: with age comes responsibility
Jain K, Gu S, Hwa J. SOD2 in platelets: with age comes responsibility. Journal Of Thrombosis And Haemostasis 2023, 21: 1077-1081. PMID: 36716965, DOI: 10.1016/j.jtha.2023.01.016.Peer-Reviewed Original Research
2022
A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences
Tyagi T, Jain K, Gu S, Qiu M, Gu V, Melchinger H, Rinder H, Martin K, Gardiner E, Lee A, Tang W, Hwa J. A guide to molecular and functional investigations of platelets to bridge basic and clinical sciences. Nature Cardiovascular Research 2022, 1: 223-237. PMID: 37502132, PMCID: PMC10373053, DOI: 10.1038/s44161-022-00021-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsVascular smooth muscle cellsPlatelet functional assaysCoronavirus disease 2019Smooth muscle cellsImmune cellsImmune regulationVascular remodelingDisease 2019Pathophysiological processesTranslational relevancePatient diagnosisFlow cytometryMuscle cellsPlatelet biologyFunctional assaysPlatelet investigationsHomeostatic processesPlateletsPhenotypic heterogeneityFunctional stateClinical scienceCellsAdditional roleThrombosisSuch diverse functionsProteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel
Mirza A, Pine A, Rasheed Y, Hamouche R, Leveille E, Goshua G, Gu S, Liu Y, VanOudenhove J, Bar N, Neparidze N, Foss F, Gowda L, Isufi I, Halene S, Lee A, Seropian S. Proteomic Profiles of Cytokine Release Syndromes Following Lisocabtagene Maraleucel and Idecabtagene Vicleucel. Blood 2022, 140: 10410-10412. DOI: 10.1182/blood-2022-168374.Peer-Reviewed Original Research
2021
Thinking outside the cavity: Effusion lymphoma primary to bone marrow
Gu SX, Pan Z, Xu ML. Thinking outside the cavity: Effusion lymphoma primary to bone marrow. Clinical Case Reports 2021, 9: e04100. PMID: 34026143, PMCID: PMC8136446, DOI: 10.1002/ccr3.4100.Peer-Reviewed Original Research
2020
Inflammation mediated platelet hyperactivity in aging.
Gu SX, Dayal S. Inflammation mediated platelet hyperactivity in aging. Annals Of Blood 2020, 5 PMID: 32524077, PMCID: PMC7286603, DOI: 10.21037/aob.2020.03.01.Peer-Reviewed Original ResearchMemantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia.
Gu SX, Sonkar VK, Katare PB, Kumar R, Kruger WD, Arning E, Bottiglieri T, Lentz SR, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal Of The American Heart Association 2020, 9: e013368. PMID: 32067580, PMCID: PMC7070222, DOI: 10.1161/JAHA.119.013368.Peer-Reviewed Original Research
2018
Targeting platelet EPCR for better therapeutic factor VIIa activity.
Gu SX, Lentz SR. Targeting platelet EPCR for better therapeutic factor VIIa activity. Journal Of Thrombosis And Haemostasis : JTH 2018, 16: 1814-1816. PMID: 29982998, PMCID: PMC6156984, DOI: 10.1111/jth.14231.Peer-Reviewed Original ResearchFibrin films: overlooked hemostatic barriers against microbial infiltration.
Gu SX, Lentz SR. Fibrin films: overlooked hemostatic barriers against microbial infiltration. The Journal Of Clinical Investigation 2018, 128: 3243-3245. PMID: 29939163, PMCID: PMC6063499, DOI: 10.1172/JCI121858.Peer-Reviewed Original ResearchCystathionine β Synthase Deficiency Exacerbates Cerebral Ischemia Reperfusion Injury Through Activation of the NMDA Receptor and Loss of Blood Brain Barrier Integrity in Mice
Gu SX, Sonkar V, Kumar R, Erland A, Bottiglieri T, Kruger W, Lentz S, Dayal S. Cystathionine β Synthase Deficiency Exacerbates Cerebral Ischemia Reperfusion Injury Through Activation of the NMDA Receptor and Loss of Blood Brain Barrier Integrity in Mice. Stroke. 2018;49(Suppl_1):AWMP80-AWMP. doi: doi:10.1161/str.49.suppl_1.WMP80.Peer-Reviewed Original ResearchDeficiency in Nox2-containing NADPH Oxidase Decreases Susceptibility to Venous Thrombosis in Mice
Sonkar VK, Kumar R, Gu S, Doddapattar P, Lentz SR, Dayal S. Genetic Deficiency in Nox2-containing NADPH Oxidase Decreases Susceptibility to Venous Thrombosis in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2018;38(Suppl_1):A305-A. doi: doi:10.1161/atvb.38.suppl_1.305.Peer-Reviewed Original Research
2017
Whole-exome sequencing in evaluation of patients with venous thromboembolism
Lee EJ, Dykas DJ, Leavitt AD, Camire RM, Ebberink E, García de Frutos P, Gnanasambandan K, Gu SX, Huntington JA, Lentz SR, Mertens K, Parish CR, Rezaie AR, Sayeski PP, Cromwell C, Bar N, Halene S, Neparidze N, Parker TL, Burns AJ, Dumont A, Yao X, Chaar CIO, Connors JM, Bale AE, Lee AI. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Advances 2017, 1: 1224-1237. PMID: 29296762, PMCID: PMC5728544, DOI: 10.1182/bloodadvances.2017005249.Peer-Reviewed Original ResearchWhole-exome sequencingVenous thromboembolismStudy patientsThrombophilia panelVTE patientsHeritable thrombophiliaThrombophilia testingDisease-causing genetic variantsEvaluation of patientsControl patientsThrombophilia mutationsProtein modelingThrombotic historyProtein structurePatientsThrombophilia genesVTE pathogenesisWES variantsUnknown significanceThrombophiliaGenetic variantsGenesPrior reportsSequencingThromboembolismDeficiency of Cystathionine beta Synthase Alters Blood Brain Barrier Integrity and Exacerbates Cerebral Ischemia Reperfusion Injury in Mice
Gu SX, Sonkar V, Kruger WD, Bottiglieri T, Lentz SR, Dayal S. Deficiency of Cystathionine beta Synthase Alters Blood Brain Barrier Integrity and Exacerbates Cerebral Ischemia Reperfusion Injury in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37(suppl_1):A146-A. doi: doi:10.1161/atvb.37.suppl_1.146.Peer-Reviewed Original Research
2016
Protein methionine oxidation augments reperfusion injury in acute ischemic stroke.
Gu SX, Blokhin IO, Wilson KM, Dhanesha N, Doddapattar P, Grumbach IM, Chauhan AK, Lentz SR. Protein methionine oxidation augments reperfusion injury in acute ischemic stroke. JCI Insight 2016, 1 PMID: 27294204, PMCID: PMC4902298, DOI: 10.1172/jci.insight.86460.Peer-Reviewed Original Research
2015
Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling.
Klutho PJ, Pennington SM, Scott JA, Wilson KM, Gu SX, Doddapattar P, Xie L, Venema AN, Zhu LJ, Chauhan AK, Lentz SR, Grumbach IM. Deletion of Methionine Sulfoxide Reductase A Does Not Affect Atherothrombosis but Promotes Neointimal Hyperplasia and Extracellular Signal-Regulated Kinase 1/2 Signaling. Arteriosclerosis, Thrombosis, And Vascular Biology 2015, 35: 2594-604. PMID: 26449752, PMCID: PMC4662651, DOI: 10.1161/ATVBAHA.115.305857.Peer-Reviewed Original ResearchDeficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis.
Dayal S, Gu SX, Hutchins RD, Wilson KM, Wang Y, Fu X, Lentz SR. Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis. Arteriosclerosis, Thrombosis, And Vascular Biology 2015, 35: 1798-804. PMID: 26069236, PMCID: PMC4514539, DOI: 10.1161/ATVBAHA.115.305963.Peer-Reviewed Original Research