1999
Nucleotide Analog Interference Mapping
Ryder S, Strobel S. Nucleotide Analog Interference Mapping. Methods 1999, 18: 38-50. PMID: 10208815, DOI: 10.1006/meth.1999.0755.Peer-Reviewed Original ResearchConceptsFunctional groupsActive moleculesGroup substitutionNucleotide analog interference mappingIncorporation propertiesIndividual analoguesMoleculesSeries 5AnaloguesSubstitution experimentsGel electrophoresisInterference mappingUnique biochemical signatureSubstitutionSynthesisNucleoside analog triphosphatesActivity assaysBiochemical informationReactionAnalog substitutionsAssayable functionChemogenetic approachRNA structureNucleotide analoguesIodine
1998
Ribozyme chemogenetics
Strobel S. Ribozyme chemogenetics. Biopolymers 1998, 48: 65-81. PMID: 9846125, DOI: 10.1002/(sici)1097-0282(1998)48:1<65::aid-bip7>3.0.co;2-d.Peer-Reviewed Original ResearchConceptsHelix-helix packing interactionsDNA-protein interactionsLarge catalytic RNAsSingle-site substitutionsRibozyme catalytic coreTetrahymena group ICatalytic coreTertiary hydrogen bondsCatalytic RNAGenetic revertantsReceptor motifRibozyme functionPacking interactionsChemogenetic approachChemical correlatesReview ISuppressorGenetic analogyRevertantsTriple helixChemical basisNucleotide analoguesModification experimentsMutagenesisRNA