Nucleotide Analog Interference Mapping of the Hairpin Ribozyme: Implications for Secondary and Tertiary Structure Formation
Ryder S, Strobel S. Nucleotide Analog Interference Mapping of the Hairpin Ribozyme: Implications for Secondary and Tertiary Structure Formation. Journal Of Molecular Biology 1999, 291: 295-311. PMID: 10438622, DOI: 10.1006/jmbi.1999.2959.Peer-Reviewed Original ResearchConceptsNucleotide analog interference mappingLoop AMinor groove edgeTertiary structure formationProper foldingThree-dimensional structureHairpin ribozymeNucleotide conservationNMR structureLoop BInterference mappingTertiary interactionsLoop B.Purine nucleotidesBiochemical evidenceRibozymeIntact ribozymeA chemogenetic approach to RNA function/structure analysis
Strobel S. A chemogenetic approach to RNA function/structure analysis. Current Opinion In Structural Biology 1999, 9: 346-352. PMID: 10361087, DOI: 10.1016/s0959-440x(99)80046-3.Peer-Reviewed Original ResearchNucleotide Analog Interference Mapping
Ryder S, Strobel S. Nucleotide Analog Interference Mapping. Methods 1999, 18: 38-50. PMID: 10208815, DOI: 10.1006/meth.1999.0755.Peer-Reviewed Original ResearchConceptsFunctional groupsActive moleculesGroup substitutionNucleotide analog interference mappingIncorporation propertiesIndividual analoguesMoleculesSeries 5AnaloguesSubstitution experimentsGel electrophoresisInterference mappingUnique biochemical signatureSubstitutionSynthesisNucleoside analog triphosphatesActivity assaysBiochemical informationReactionAnalog substitutionsAssayable functionChemogenetic approachRNA structureNucleotide analoguesIodine