Dual Genetic Encoding of Acetyl‐lysine and Non‐deacetylatable Thioacetyl‐lysine Mediated by Flexizyme
Xiong H, Reynolds NM, Fan C, Englert M, Hoyer D, Miller SJ, Söll D. Dual Genetic Encoding of Acetyl‐lysine and Non‐deacetylatable Thioacetyl‐lysine Mediated by Flexizyme. Angewandte Chemie International Edition 2016, 55: 4083-4086. PMID: 26914285, PMCID: PMC4789153, DOI: 10.1002/anie.201511750.Peer-Reviewed Original ResearchConceptsPost-translational modificationsHistone H3Post-translational protein modificationImportant post-translational protein modificationHuman histone H3Non-histone proteinsFull-length proteinTranscriptional regulationLysine acetylationDNA replicationProtein acetylationDNA repairProtein modificationGenetic encodingLysine residuesAcetyl lysineAcetylationHistonesLysine positionsH3ProteinFlexizymesCrosstalkPowerful toolResidues