Multivalency as a Key Factor for High Activity of Selective Supported Organocatalysts for the Baylis–Hillman Reaction
Goren K, Karabline‐Kuks J, Shiloni Y, Barak‐Kulbak E, Miller SJ, Portnoy M. Multivalency as a Key Factor for High Activity of Selective Supported Organocatalysts for the Baylis–Hillman Reaction. Chemistry - A European Journal 2014, 21: 1191-1197. PMID: 25376519, DOI: 10.1002/chem.201404560.Peer-Reviewed Original ResearchConceptsNew carbon-carbon bondsCarbon-carbon bondsRate-determining proton transferThird generation analoguesMethyl vinyl ketoneBaylis–Hillman reactionAnalogous catalystsDendritic catalystsSupported OrganocatalystsImidazole unitsDendritic effectReaction solventIntermediate adductModel reactionProton transferImidazole moietyActive substratesVinyl ketoneCatalystP-nitrobenzaldehydeReaction yieldMultivalent architectureHigh activityContent of waterHigher generations