A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities
Ricard J, Labache L, Segal A, Dhamala E, Cocuzza C, Jones G, Yip S, Chopra S, Holmes A. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D2/3 receptor densities. Communications Biology 2024, 7: 1178. PMID: 39300138, PMCID: PMC11413242, DOI: 10.1038/s42003-024-06836-9.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainCocaine-Related DisordersConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyReceptors, Dopamine D2Receptors, Dopamine D3ConceptsCocaine use disorderPatterns of functional connectivityUse disorderFunctional connectivityReceptor densityLarge-scale functional brain networksMaintenance of substance useDopamine D2/3 receptorsDopamine receptor densityCortico-striatal circuitsProfile of functional connectivitySubstance use disordersFunctional brain networksNeurotransmitter receptor densityD2/3 receptorsDopamine systemTransporter bindingSubcortical systemsBrain networksSubstance useCocaineSpatial topographyDisordersDopamineBiological mechanisms