2017
White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine
Morie KP, Yip SW, Zhai ZW, Xu J, Hamilton KR, Sinha R, Mayes LC, Potenza MN. White-matter crossing-fiber microstructure in adolescents prenatally exposed to cocaine. Drug And Alcohol Dependence 2017, 174: 23-29. PMID: 28292689, PMCID: PMC5555052, DOI: 10.1016/j.drugalcdep.2017.01.011.Peer-Reviewed Original ResearchConceptsPrenatal cocaine exposureSuperior longitudinal fasciculusPCE adolescentsCrossing-fiber modelsGroup differencesWhole-brain investigationNon-exposed youthWhole-brain analysisSignificant group differencesAltered white matter developmentLeft superior longitudinal fasciculusRisk-taking behaviorNeurobiological underpinningsWhite matter developmentWhite matter microstructureSubstance useWhite matter differencesWhite matter regionsAdolescentsDiffusion-weighted imaging dataCocaine exposureLongitudinal cohortBilateral cingulumCorpus callosumROI analysisGray‐matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions
Yip SW, Worhunsky PD, Xu J, Morie KP, Constable RT, Malison RT, Carroll KM, Potenza MN. Gray‐matter relationships to diagnostic and transdiagnostic features of drug and behavioral addictions. Addiction Biology 2017, 23: 394-402. PMID: 28150390, PMCID: PMC5538947, DOI: 10.1111/adb.12492.Peer-Reviewed Original Research
2014
Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder
Yip SW, Worhunsky PD, Rogers RD, Goodwin GM. Hypoactivation of the Ventral and Dorsal Striatum During Reward and Loss Anticipation in Antipsychotic and Mood Stabilizer-Naive Bipolar Disorder. Neuropsychopharmacology 2014, 40: 658-666. PMID: 25139065, PMCID: PMC4289954, DOI: 10.1038/npp.2014.215.Peer-Reviewed Original ResearchConceptsDorsal striatumUnmedicated individualsLoss anticipationPotential ameliorative effectsAddiction-related disordersBipolar disorder IReward processingMonetary incentive delay taskSmall volume correctionFunctional magnetic resonanceIncentive delay taskAntipsychotic medicationVentral striatal activityHealthy comparison individualsPutamen volumeBipolar disorderBD-IIAmeliorative effectMedicated individualsStriatal activityDisorder IStriatumGroup comparisonsNeural activationReward anticipation
2013
Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy
Godlewska BR, Yip SW, Near J, Goodwin GM, Cowen PJ. Cortical glutathione levels in young people with bipolar disorder: a pilot study using magnetic resonance spectroscopy. Psychopharmacology 2013, 231: 327-332. PMID: 23955702, DOI: 10.1007/s00213-013-3244-0.Peer-Reviewed Original ResearchConceptsBipolar disorderGSH levelsOccipital cortexHealthy age-matched controlsPilot studyDSM-IV bipolar disorderPost-mortem brain tissueConclusionsThis pilot studyAge-matched controlsProton magnetic resonance spectroscopyTime of studyMagnetic resonance spectroscopyCortical GSHIll patientsCortical metabolitesΓ-aminobutyric acidCellular free radicalsMood disturbanceUseful biomarkerBipolar pathophysiologyPatientsTrait biomarkerBrain tissueGlutathione levelsObjectivesThe objective