2023
Brain Networks and Adolescent Alcohol Use
Yip S, Lichenstein S, Liang Q, Chaarani B, Dager A, Pearlson G, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Garavan H. Brain Networks and Adolescent Alcohol Use. JAMA Psychiatry 2023, 80: 1131-1141. PMID: 37647053, PMCID: PMC10469292, DOI: 10.1001/jamapsychiatry.2023.2949.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestAlcohol use riskAlcohol misuseUse riskAlcohol use disorderMale adolescentsDisorders Identification TestSingle-site studyIntervention effortsWhole-brain patternsMean ageAlcohol use dataLeading causeMagnetic resonance imaging dataMAIN OUTCOMEReward-related processesHigh riskSeparate cohortUse disordersAlcohol consumptionCurrent severityAdolescent neurodevelopmentAlcohol use behaviorsAlcohol useAUDIT scoresDistinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment responders
2022
THC, CBD, and Anxiety: a Review of Recent Findings on the Anxiolytic and Anxiogenic Effects of Cannabis’ Primary Cannabinoids
Lichenstein S. THC, CBD, and Anxiety: a Review of Recent Findings on the Anxiolytic and Anxiogenic Effects of Cannabis’ Primary Cannabinoids. Current Addiction Reports 2022, 9: 473-485. PMID: 38106452, PMCID: PMC10722902, DOI: 10.1007/s40429-022-00450-7.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRegular cannabis usersAnxiogenic effectsSubstance use disordersImpact anxietyEffects of THCAnxiety disordersCannabis usersClinical populationsHealthy participantsAnxietyTHC administrationLegalization of cannabisUse disordersEffects of CBDSex differencesPurpose of ReviewInSummaryFuture researchRecent FindingsRecent literatureCannabisAnxiolytic effectsRecreational cannabisCBD administrationEarlier findingsMost new studiesTherapeutic potential
2019
Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling
Lichenstein SD, Scheinost D, Potenza MN, Carroll KM, Yip SW. Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling. Molecular Psychiatry 2019, 26: 4383-4393. PMID: 31719641, PMCID: PMC7214212, DOI: 10.1038/s41380-019-0586-y.Peer-Reviewed Original ResearchConceptsBrain statesDissociable neural substratesMultiple brain statesSubstance use outcomesHealthy comparison subjectsWhole-brain approachFMRI scanningFrontoparietal networkNeural substratesSubstance use treatmentNeural mechanismsDifferent brain statesFurther clinical relevanceDefault modeFMRI dataSubject replicationTreatment approachesReduced connectivityUse outcomesComparison subjectsNetwork strengthUse disordersSensory networksTreatment respondersSensory connectivity