2010
Aplidin as a potential adjunct to radiation therapy: In vitro studies
Rockwell S, Liu Y. Aplidin as a potential adjunct to radiation therapy: In vitro studies. International Journal Of Radiation Biology 2010, 86: 63-70. PMID: 20070217, PMCID: PMC2837581, DOI: 10.3109/09553000903264531.Peer-Reviewed Original ResearchConceptsH drug treatmentDrug treatmentPhase II clinical trialEMT6 mouse mammary tumor cellsGy of radiationMouse mammary tumor cellsMammary tumor cellsBystander effectSupraadditive cytotoxicityTherapeutic regimensHematologic malignanciesClinical trialsRadiation therapyModerate hypoxiaActive metaboliteSevere hypoxiaTumor cellsUntreated cellsTreatmentCytotoxicityHypoxiaAplidinKV X-raysCellsMonolayer cultures
1991
Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur)
Rockwell S, Grindey G. Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur). Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1991, 3: 103-108. PMID: 2025495, DOI: 10.3727/095535491820873434.Peer-Reviewed Original ResearchConceptsEMT6 mouse mammary tumor cellsMouse mammary tumor cellsMammary tumor cellsAcute hypoxiaSolid tumorsSulofenurTumor cellsCytotoxic effectsCulture mediumVitro studyPlateau-phase culturesDiarylsulfonylureasCytotoxicityDrugsFurther examinationProliferative stateMonolayer culturesQuiescent cellsTreatmentCritical determinantCellsRadiotherapy
1984
Enhancement of artificial lung metastases by misonidazole
Rockwell S, Nierenburg M, Irvin C. Enhancement of artificial lung metastases by misonidazole. International Journal Of Radiation Oncology • Biology • Physics 1984, 10: 1395-1398. PMID: 6469763, DOI: 10.1016/0360-3016(84)90356-0.Peer-Reviewed Original ResearchConceptsArtificial lung metastasesLung metastasesHypoxic cell radiosensitizer misonidazoleEMT6 mouse mammary carcinoma cellsLung tumor formationMouse mammary carcinoma cellsEffect of treatmentMammary carcinoma cellsLung tumorsIntravenous injectionPhysiologic effectsLarge dosesRadiosensitizer misonidazoleSmall dosesSingle treatmentCarcinoma cellsMisonidazoleTumor formationMetastasisTreatmentDosesTumors