Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio.
Rockwell S, Nierenburg M, Irvin C. Effects of the mode of administration of mitomycin on tumor and marrow response and on the therapeutic ratio. Journal Of The National Cancer Institute 1987, 71: 927-34. PMID: 3652056.Peer-Reviewed Original ResearchConceptsDoses of mitomycinTherapeutic ratioSingle injectionDaily injectionsAntineoplastic effectsSurvival curvesEMT6 mouse mammary tumorsHost toxicityBALB/c miceLarge single doseTumor growth assaysEffect of mitomycinLess host toxicityMouse mammary tumorsResponse of tumorsBone marrow stem cellsMode of administrationMarrow stem cellsSublethal lesionsMarrow responseDaily fractionsSingle doseTumor responseC miceClinical impression