WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A
BOOTH CJ, BROOKS MB, ROCKWELL S, MURPHY JW, RINDER HM, ZELTERMAN D, PAIDAS MJ, COMPTON SR, MARKS PW. WAG‐F8m1Ycb rats harboring a factor VIII gene mutation provide a new animal model for hemophilia A. Journal Of Thrombosis And Haemostasis 2010, 8: 2472-2477. PMID: 20626616, DOI: 10.1111/j.1538-7836.2010.03978.x.Peer-Reviewed Original ResearchConceptsAutosomal locationX chromosomeGenetic basisFactor VIIITertiary structureChromosome 18Point mutationsA1 domainFactor activityGenetic defectsHuman recombinant factor VIIIPartial thromboplastin timeSpecific coagulation factorsNew animal modelNormal prothrombin timeFactor VIII gene mutationsRecombinant factor VIIIMutationsPeripartum deathsGene mutationsCoagulation abnormalitiesSpontaneous bruisingProthrombin timeFemale ratsNovel therapies