2017
Salinomycin induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells
Yu S, Kim S, Kim K, Ji J, Seo Y, Yu H, Ahn S. Salinomycin induces endoplasmic reticulum stress-mediated autophagy and apoptosis through generation of reactive oxygen species in human glioma U87MG cells. Oncology Reports 2017, 37: 3321-3328. PMID: 28498472, DOI: 10.3892/or.2017.5615.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesER stressHuman glioma U87MG cellsEndoplasmic reticulumGlioma U87MG cellsU87MG cellsStress-related proteinsAcidic vesicular organellesOxygen speciesER stress-related proteinsHuman cancer cellsAutophagy marker proteinsVesicular organellesImpact of salinomycinEndoplasmic reticulum stress-mediated autophagyMolecular mechanismsCell deathAutophagyMarker proteinsAutophagy inhibitorCancer cell linesGlioma cancer cell linesInduced apoptosisROS scavengerExpression levels
2013
Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells
Kim S, Kim K, Yu S, Park S, Kong I, Ahn S. Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb103-lb103. DOI: 10.1096/fasebj.27.1_supplement.lb103.Peer-Reviewed Original ResearchPC-3 cellsHuman prostate cancer PC-3 cellsProstate cancer PC-3 cellsSilibinin-induced apoptosisCancer PC-3 cellsER stress-related proteinsStress-related proteinsReactive oxygen speciesER stressDNA damage-inducible gene 153Cancer cellsRWPE-1 cellsChelator BAPTA/AMProstate cancer cellsDrug-induced lethalityGlucose-regulated protein 78Mitochondrial-mediated apoptosisFlow cytometric analysisMitochondrial membrane potentialApoptosis-related proteinsBAPTA/AMCancer cell linesSilibinin treatmentChemopreventive effectsDisruption of Ca2