2017
Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells
Kim K, Kim S, Yu S, Park S, Kim Y, Nam H, An H, Yu H, Kim Y, Ji J, Seo Y, Ahn S. Lasalocid induces cytotoxic apoptosis and cytoprotective autophagy through reactive oxygen species in human prostate cancer PC-3 cells. Biomedicine & Pharmacotherapy 2017, 88: 1016-1024. PMID: 28178613, DOI: 10.1016/j.biopha.2017.01.140.Peer-Reviewed Original ResearchConceptsProstate cancer cellsHuman prostate cancer cellsAcidic vesicular organelles (AVOs) formationApoptotic cell death pathwayCancer cellsCell death pathwaysProtein 1 light chain 3Cell cycle arrestLight chain 3Human prostate cancer PC-3 cellsProstate cancer PC-3 cellsReactive oxygen species productionPossible signal pathwaysCancer PC-3 cellsInhibition of autophagyOrganelle formationDeath pathwaysNew potential chemotherapeutic agentsReactive oxygen speciesOxygen species productionMitochondrial hyperpolarizationMolecular mechanismsPotential chemotherapeutic agentProduction of ROSCytoprotective autophagy
2016
Monensin Induces PC-3 Prostate Cancer Cell Apoptosis via ROS Production and Ca2+ Homeostasis Disruption
KIM S, KIM K, YU S, PARK S, YU H, SEO Y, AHN S. Monensin Induces PC-3 Prostate Cancer Cell Apoptosis via ROS Production and Ca2+ Homeostasis Disruption. Anticancer Research 2016, 36: 5835-5843. PMID: 27793906, DOI: 10.21873/anticanres.11168.Peer-Reviewed Original ResearchConceptsCell cycle arrestApoptosis-related proteinsCell cycleCancer cellsPoly ADP-ribose polymerase (PARP) cleavageADP-ribose polymerase cleavageDisruption of CaProstate cancer cell apoptosisRibose polymerase cleavagePhase cell cycle arrestHuman prostate cancer cellsCell viabilityReactive oxygen species productionCancer cell apoptosisAnticancer effectsOxygen species productionMitochondrial ROS inhibitorProduction of ROSMitochondrial ROSDependent apoptosisProstate cancer cellsProstate cell linesPolymerase cleavageCell growth inhibitionPC-3 cellsSilibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis
Kim S, Kim K, Yu S, Seo Y, Chun S, Yu H, Ahn S. Silibinin induces mitochondrial NOX4-mediated endoplasmic reticulum stress response and its subsequent apoptosis. BMC Cancer 2016, 16: 452. PMID: 27405931, PMCID: PMC4942927, DOI: 10.1186/s12885-016-2516-6.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesNOX4 expressionDisruption of Ca2ER stress responseProstate cancer PC-3 cellsCancer PC-3 cellsRegulation of NOX4Inhibited tumor growthCell linesPC-3 cellsProstate cell linesSilibinin-induced apoptosisProduction of ROSEndoplasmic reticulum stress responseExpression of apoptosisCancer cell linesProstate cancerROS-dependent apoptosisChemopreventive effectsMitochondrial Nox4Mitochondrial reactive oxygen speciesReticulum stress responseTumor growthFlow cytometryMethodsThe effects