Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells
Kim S, Kim K, Yu S, Park S, Kong I, Ahn S. Silibinin induces endoplasmic reticulum stress‐mediated and mitochondrial‐mediated apoptosis through disruption of Ca2+ homeostasis in human prostate cancer PC‐3 cells. The FASEB Journal 2013, 27: lb103-lb103. DOI: 10.1096/fasebj.27.1_supplement.lb103.Peer-Reviewed Original ResearchPC-3 cellsHuman prostate cancer PC-3 cellsProstate cancer PC-3 cellsSilibinin-induced apoptosisCancer PC-3 cellsER stress-related proteinsStress-related proteinsReactive oxygen speciesER stressDNA damage-inducible gene 153Cancer cellsRWPE-1 cellsChelator BAPTA/AMProstate cancer cellsDrug-induced lethalityGlucose-regulated protein 78Mitochondrial-mediated apoptosisFlow cytometric analysisMitochondrial membrane potentialApoptosis-related proteinsBAPTA/AMCancer cell linesSilibinin treatmentChemopreventive effectsDisruption of Ca2