2017
Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release
Mishra S, Kannan S. Doxorubicin-Conjugated Bimetallic Silver–Gadolinium Nanoalloy for Multimodal MRI-CT-Optical Imaging and pH-Responsive Drug Release. ACS Biomaterials Science & Engineering 2017, 3: 3607-3619. PMID: 33445395, DOI: 10.1021/acsbiomaterials.7b00498.Peer-Reviewed Original ResearchBimetallic nanoparticlesMicrowave-assisted polyol synthesisPH-sensitive hydrazone linkageDrug releaseResponsive drug releaseNegligible drug releaseOne-pot synthesisBimetallic silverCancer theranosisContrast abilityCapping agentPolyol synthesisAverage sizeHydrazone linkagePotential anticancer drugsAcidic mediumContrast performanceOptical imagingParamagnetic behaviorPhysiological pHMolar ratioChitosanAnticancer drugsAgDOXA Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy
Mishra SK, Kannan S. A Bimetallic Silver–Neodymium Theranostic Nanoparticle with Multimodal NIR/MRI/CT Imaging and Combined Chemo-photothermal Therapy. Inorganic Chemistry 2017, 56: 12054-12066. PMID: 28933536, DOI: 10.1021/acs.inorgchem.7b02103.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAntineoplastic AgentsChitosanContrast MediaDrug CarriersDrug LiberationGreen Chemistry TechnologyHeatingHeLa CellsHumansMagnetic Resonance ImagingMetal NanoparticlesMultimodal ImagingNeodymiumOptical ImagingPaclitaxelParticle SizeSilverTheranostic NanomedicineTomography, X-Ray ComputedConceptsChemo-photothermal therapyPhotothermal effectMicrowave-assisted polyol synthesisCombined chemo-photothermal therapyMRI/CT imagingEfficient photothermal effectHigh loading efficiencyLoading of paclitaxelTheranostic nanoparticlesBimetallic nanoparticlesMetallic nanostructuresGood monodispersityPolyol synthesisNIR laserLoading efficiencyAverage sizeNanoparticlesGood biocompatibilityMultimodal imagingInfrared regionExcellent candidateNIR imagingChitosan functionalizationSynergistic effectDrug molecules
2016
Microwave Synthesis of Chitosan Capped Silver–Dysprosium Bimetallic Nanoparticles: A Potential Nanotheranosis Device
Mishra SK, Kannan S. Microwave Synthesis of Chitosan Capped Silver–Dysprosium Bimetallic Nanoparticles: A Potential Nanotheranosis Device. Langmuir 2016, 32: 13687-13696. PMID: 27981845, DOI: 10.1021/acs.langmuir.6b03438.Peer-Reviewed Original ResearchBimetallic nanoparticlesX-ray photoelectron spectroscopyAnnular dark-field scanning transmission electron microscopyHigh-angle annular dark-field scanning transmission electron microscopyDark-field scanning transmission electron microscopyScanning transmission electron microscopyInfrared (NIR-II) biological windowGreen chemistry routeTransmission electron microscopyX-ray attenuation effectTheranostic devicesMicrowave synthesisBiological windowChemistry routeNanoparticlesIndividual imagingPhotoelectron spectroscopyGood biocompatibilityHigh relaxivityMetallic stateDy-componentsParamagnetic featuresElectron microscopyCharacterization resultsBiological targets