Synthesis of Stabilized Alpha-Helical Peptides
Bernal F, Katz SG. Synthesis of Stabilized Alpha-Helical Peptides. Methods In Molecular Biology 2014, 1176: 107-114. PMID: 25030922, PMCID: PMC6333094, DOI: 10.1007/978-1-4939-0992-6_9.Peer-Reviewed Original ResearchConceptsAlpha-helical peptidesImportant protein-protein interactionsSpecific amino acid residuesProtein-protein interactionsAlpha-helical motifOlefin metathesis reactionsAlpha-helical structureRing-closing olefin metathesis reactionAmino acid residuesPosttranslational modificationsProtein interactionsMetathesis reactionHost proteinsProtein targetsAcid residuesCrystal structureSecondary structureFunctional consequencesRemarkable stabilitySmall moleculesMost peptidesInteraction sitesStructural studiesCell permeabilitySynthesis