2020
Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative‐Mediated Intraperitoneal Photodynamic Therapy in a Canine Model
Cramer G, Lewis R, Gymarty A, Hagan S, Mickler M, Evans S, Punekar S, Shuman L, Simone C, Hahn S, Busch T, Fraker D, Cengel K. Preclinical Evaluation of Cetuximab and Benzoporphyrin Derivative‐Mediated Intraperitoneal Photodynamic Therapy in a Canine Model. Photochemistry And Photobiology 2020, 96: 684-691. PMID: 32119123, DOI: 10.1111/php.13247.Peer-Reviewed Original ResearchConceptsIntraperitoneal photodynamic therapySmall bowel resectionPeritoneal carcinomatosisEpidermal growth factor receptorCanine modelPhotodynamic therapyPoor survival profilesMultiple primary malignanciesEGFR inhibitor cetuximabBPD levelsGrowth factor receptorBowel resectionCancer presentationPrimary malignancySurgical resectionTolerable safetySmall bowelAnastomotic failureIdeal treatmentToxicity profilePreclinical evaluationTherapeutic indexSurface tumorsPC treatmentEGFR inhibitors
2012
Radical Pleurectomy and Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma
Friedberg J, Culligan M, Mick R, Stevenson J, Hahn S, Sterman D, Punekar S, Glatstein E, Cengel K. Radical Pleurectomy and Intraoperative Photodynamic Therapy for Malignant Pleural Mesothelioma. The Annals Of Thoracic Surgery 2012, 93: 1658-1667. PMID: 22541196, PMCID: PMC4394024, DOI: 10.1016/j.athoracsur.2012.02.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCohort StudiesCombined Modality TherapyDisease-Free SurvivalFemaleFollow-Up StudiesHumansImmunohistochemistryIntraoperative CareMaleMesotheliomaMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPhotochemotherapyPleuraPleural NeoplasmsRisk AssessmentSurvival AnalysisTime FactorsTreatment OutcomeConceptsProgression-free survivalMacroscopic complete resectionRadical pleurectomyIntraoperative photodynamic therapyNonepithelial subtypeMedian survivalComplete resectionEpithelial subtypesStage III/IV diseaseMedian progression-free survivalStage III/IV cancerPhotodynamic therapyLung-sparing approachLung-sparing surgeryMalignant pleural mesotheliomaPostoperative mortalitySystemic therapyPleural mesotheliomaEpithelial diseasePatientsMesotheliomaSubtypesTherapyMonthsSurvival